CAS: 14510-37-3; Tropoylchlorideacetate

主要参考文献

参考标题: Process For Preparation Of Atropine Procédé De Préparation D'Atropine
摘要:A Process For The Production Of Atropine Is Provided. The Process Provides For A New, Efficient And Commercially Feasible Synthetic Process For The Preparation Of Atropine And Atropine Salts. In One Aspect, A One Pot Process For The Synthesis Of Atropine Is Provided. The Process Provides Excellent Yield And Can Be Used To Prepare Commercial 5 Scale Batches Of Atropine Or Atropine Salts. The Process Avoids The Additional Steps Of Having To Isolate Intermediates To Complete The Process And Has The Advantage Of Proceeding Efficiently At Ambient Temperature For Many Of The Steps. The Process Includes Providing Acetyltropoyl Chloride And Reacting The Acetyltropoyl Chloride With Tropine Followed By A Contact With An Acid To Form Atropine.

合成参考文献

摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).