CAS: 144-29-6; Piperazine Citrate

哌嗪,柠檬酸 以 乙醇 用作溶剂,化学反应 3.6H,反应生成哌嗪柠檬酸盐水合物
参考文献:Cn103159700
标题:Cn103159700

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2025188502-A1
优先权日:2022-03-10
标 题 :Biocatalyst and method for the synthesis of ubrogepant intermediates
发明人：CHEN HAIBIN; HU HU; CAI BAOQIN; XU JUNPENG; LIU SITONG; JIN LUPING; WU XINWEI; CUI QINYAN; ZHANG CHENGXIAO; ZHU KAILONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:This application provides engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. This application also provides a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.

专利号:WO-2025038767-A1
优先权日:2023-08-14
标 题:Cell-free synthesis platform for synthetically dimierized, clickable fragment antigen-binding (fab) fragments
发明人：THAMES ARIEL; RISCHE CLAYTON; JEWETT MICHAEL; BOCHNER BRUCE
权利人:UNIV NORTHWESTERN
摘要:Disclosed are components, systems, methods, and kits for synthesis of diamerized, clickable antigen binding fragments, such as Fab fragments, and uses thereof. The components, systems, methods, and kits disclosed herein utilize cell-free protein synthesis (CFPS) systems and methods to produce clickable antigen binding fragments.

专利号:US-12442025-B2
优先权日:2019-04-07
标 题:Engineered polypeptides and its application in the synthesis of tyrosine or tyrosine derivatives
发明人：CHEN HAIBIN; ZHANG CHENGXIAO; SHI SHUMIN; CAI BAOQIN; SUN LEI; PENG QINLI; WANG ZIKUN; BONG YONG KOY
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:Provided are efficient catalyst of engineered enzymes and an economical enzymatic reaction solution to solve the problems in the current production process of L-tyrosine and its derivatives. The method of the invention has the advantages of high product concentration, mild reaction conditions, simple purification process, simple operation, environmental friendliness, and easy industrial scale-up. Thus, it has good industrial application prospects.

专利号:WO-2023169184-A1
优先权日:2022-03-10
标 题:Biocatalyst and method for the synthesis of ubrogepant intermediates

专利号:US-2023010880-A1
优先权日:2019-04-07
标 题 :Engineered polypeptides and its application in the synthesis of tyrosine or tyrosine derivatives