CAS: 1380049-42-2; 2-(3-Formyl-4-Isobutoxyphenyl)-N,N,4-Trimethylthiazole-5-Carboxamide

英文名称2-(3-Formyl-4-Isobutoxyphenyl)-N,N,4-Trimethylthiazole-5-Carboxamide
中文名称非布索坦杂质65
IUPAC名称2-(3-formyl-4-isobutoxyphenyl)-N,N,4-trimethylthiazole-5-carboxamide
其它别名2-(3-Formyl-4-Isobutoxyphenyl)-N,N,4-Trimethylthiazole- 5-Carboxamide; Febuxostat Impurity 61/2-(3-Formyl-4-Isobutoxyphenyl)-N,N,4-Trimethylthiazole- 5-Carboxamide; Febuxostat-63; 5-Thiazolecarboxamide, 2-[3-Formyl-4-(2-Methylpropoxy)Phenyl]-N,N,4-Trimethyl-
CAS编号1380049-42-2
分子式:C18H22N2O3S分子量:346.45
产品CID: 592510
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: QTUURZAFIAGQRN-UHFFFAOYSA-N
InChI=1S/C18H22N2O3S/c1-11(2)10-23-15-7-6-13(8-14(15)9-21)17-19-12(3)16(24-17)18(22)20(4)5/h6-9,11H,10H2,1-5H3
计算化学: 氢键受体数5.0氢键供体数0.0可旋转键数6.0

MSDS等安全信息

上下游产品

Isobutyl bromide 2-(3-formyl-4-hydroxyphenyl)-N,N,4-trimethylthiazole-5-carboxamide 2-(4-hydroxyphenyl)-N,N-4-trimethylthiazole-5-carboxamide febuxostat 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

合成工艺路线路线简述

合成目标产物 2-(3-Formyl-4-Isobutoxyphenyl)-N,N,4-Trimethylthiazole- 5-Carboxamide 主要起始原料 1-Bromo-2-Methylpropane And 5-Thiazolecarboxamide, 2-(3-Formyl-4-Hydroxyphenyl)-N,N,4-Trimethyl-
(文献来源)合成步骤主要原料 1-Bromo-2-Methylpropane 和 5-Thiazolecarboxamide, 2-(3-Formyl-4-Hydroxyphenyl)-N,N,4-Trimethyl-

📜2-(4-Hydroxyphenyl)-N,N-4-Trimethylthiazole-5-Carboxamide置于四丁基溴化铵,Potassium Carbonate,Potassium Iodide体系中,用四氢呋喃,N,N-二甲基甲酰胺用作溶剂,化学反应 0.5H,反应生成非布索坦杂质65
参考文献: Novel Process For The Preparation Of Febuxostat[fr] Nouveau Procédé Pour La Préparation De Febuxostat
标题: Novel Process For The Preparation Of Febuxostat[fr] Nouveau Procédé Pour La Préparation De Febuxostat
摘要:本文披露了一种用于制备2-[3-氰基-4-(2-甲基丙氧基)苯基]-4-甲基噻唑-5-羧酸及其新型中间体的新工艺.