CAS: 13301-04-7; Methyl 3,6-Dibromopyrazine-2-Carboxylate

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CAS号6966-01-4 3-氨基-6-溴吡嗪-2-甲酸甲酯 | CAS号16298-03-6 3-氨基吡嗪-2-羧酸甲酯 | CAS号5424-01-1 3-氨基吡嗪-2-羧酸 | CAS号957230-68-1 3,6-二溴吡嗪-2-甲酸

3-氨基吡嗪-2-羧酸置于硫酸,氢溴酸,溴,溶剂黄146,Sodium Nitrite体系中,用 水 用作溶剂,化学反应生成3,6-二溴吡嗪-2-甲酸甲酯
参考文献:Discovery Of A Series Of Imidazopyrazine Small Molecule Inhibitors Of The Kinase Mapkapk5,That Show Activity Using In Vitro And In Vivo Models Of Rheumatoid Arthritis
标题:Discovery Of A Series Of Imidazopyrazine Small Molecule Inhibitors Of The Kinase Mapkapk5,That Show Activity Using In Vitro And In Vivo Models Of Rheumatoid Arthritis
摘要:Mapkapk5 Has Been Proposed To Play A Role In Regulation Of Matrix Metalloprotease Expression And So To Be A Potential Target For Intervention In Rheumatoid Arthritis. We Present Here The Identification Of A Series Of Compounds Against This Target Which Are Effective In Both Biochemical And Cell Assays. The Expansion Of The Series Is Described,Along With Early Sar And Pharmacokinetics For Some Representative Compounds. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2012.01.077