专利号:US-6376475-B1 优先权日:1997-05-30 标 题 :Control of immune responses by modulating activity of glycosyltransferases 发明人:MARTH JAMEY D; PAULSON JAMES C 权利人:ABARON BIOSCIENCES INC; UNIV CALIFORNIA 摘要:The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of α2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of α2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.
专利号:US-9567307-B2 优先权日:2011-01-07 标题:Amination of aryl alcohol derivatives 发明人:GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W 权利人:GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W; UNIV CALIFORNIA 摘要:Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates, which are attractive cross-coupling partners, particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid.
专利号:US-5232829-A 优先权日:1989-09-29 标 题 :Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes 发明人:LONGIARU MATHEW; SILVER SHERYL B; SULZINSKI MICHAEL A 权利人:HOFFMANN LA ROCHE 摘要:The present invention relates to the synthesis of amplified biotin-labelled DNA target sequences of Chlamydia trachomatis by polymerase chain reaction techniques and the detection of such sequences by a microtiter plate having plurality of wells and having bound thereto oligonucleotide capture probe complementary to said target sequence.
专利号:EP-0942745-B1 优先权日:1996-08-26 标题:Use of hyaluronidase 发明人:TUFVESON GUNNAR; HAELLGREN ROGER; JOHNSSON CECILIA; WAHLBERG JAN 权利人:TUFVESON GUNNAR; HAELLGREN ROGER; JOHNSSON CECILIA; WAHLBERG JAN 摘要:The use of hyaluronidase in the manufacturing of a drug for the treatment of conditions of interstitial edema in connection with organ grafting associated with an increased local content of hyaluronan in the connective tissue of a mammal. The drug comprises hyaluronidase in an amount giving a daily dosage of from 1 to 100,000 IU/kg body weight when given locally or systemically to a mammal. A method of treating conditions of interstitial edema in connection with organ grafting associated with an increased local synthesis of hyaluronan by systemic or local treatment with a pharmaceutical comprising hyaluronidase.
专利号:US-6251663-B1 优先权日:1996-04-24 标题 :Recombinant eukaryotic plasmids containing allergen-gene and use thereof for the prevention and/or treatment of allergic diseases 发明人:HSU CHING-HSIANG; CHUA KAW-YAN; TAO MI-HUA; HSIEH KUE-HSIUNG 权利人:JEN WEN CO LTD 摘要:The present invention relates to recombinant eukaryotic plasmids comprising an eukaryotic expression vector and an allergen gene for the prevention and/or treatment of allergic diseases. When the recombinant vector containing allergen-gene administrate to an individual in need of such prevention and/or treatment by intramuscular injection, intranasal delivery or intratracheal delivery, the production of allergen-specific IgE synthesis can be inhibited. The invention also relates to the pharmaceutical compositions comprising the the recombinant vector for use in the the prevention and/or treatment of allergic diseases and the production of allergen-specific IgE synthesis. A method for the prevention and/or treatment of allergic diseases is also provided.
专利号:US-5780675-A 优先权日:1995-04-28 标 题:Deoxygossylic compounds 发明人:ROYER ROBERT D; DECK LORRAINE M; VANDERJAGT DAVID L 权利人:UNIV NEW MEXICO 摘要:The invention provides deoxygossylic compounds having useful biological activities, and methods for the synthesis of these and related compounds. The invention further provides valuable intermediates for the synthesis of the compounds, and pharmaceutical compositions containing biologically active compounds according to the invention.
[参考文献]: A Bertolo, Et Al. Injectable Microcarriers As Human Mesenchymal Stem Cell Support And Their Application For Cartilage And Degenerated Intervertebral Disc Repair. Eur Cell Mater. 2015 Jan 12:29:70-80; Discujssion 80-1. [参考文献]: L M M Costes, Et Al. Endogenous Vagal Activation Dampens Intestinal Inflammation Independently Of Splenic Innervation In Postoperative Ileus. Auton Neurosci. 2014 Oct:185:76-82. [参考文献]: Lisa G M Van Baarsen, Et Al. Heterogeneous Expression Pattern Of Interleukin 17A (Il-17A), Il-17F And Their Receptors In Synovium Of Rheumatoid Arthritis, Psoriatic Arthritis And Osteoarthritis: Possible Explanation For Nonresponse To Anti-Il-17 Therapy. Arthritis Res Ther. 2014 Aug 22;16(4):426. [参考文献]: M Trondsen, Et Al. Induction Of Local Secretory Iga And Multifunctional Cd4 T-Helper Cells Following Intranasal Immunization With A H5N1 Whole Inactivated Influenza Virus Vaccine In Balb/c Mice. Scand J Immunol. 2015 May;81(5):305-17. [参考文献]: Phuong N Dang, Et Al. Driving Cartilage Formation In High-Density Human Adipose-Derived Stem Cell Aggregate And Sheet Constructs Without Exogenous Growth Factor Delivery. Tissue Eng Part A. 2014 Dec;20(23-24):3163-75.
合成参考文献
参考文献:10.1186/1743-422x-7-38 摘要:Van Poucke SG, Nicholls JM, Nauwynck HJ, Van Reeth K. Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution. Virology Journal. 2010 Feb 16;7(1):38. doi: 10.1186/1743-422x-7-38. 参考文献:10.1186/1756-0500-4-235 摘要:Côté M, Provost PR, Tremblay Y. Apolipoprotein A-I, A-II, and H mRNA and protein accumulation sites in the developing lung in late gestation. BMC Research Notes. 2011 Jul 14;4(1):235. doi: 10.1186/1756-0500-4-235. 参考文献:10.1007/s11262-011-0642-4 摘要:Zhang C, Liu L, Wang P, Liu S, Lin W, Hu F, Wu W, Chen W, Cui S. A potentially novel reovirus isolated from swine in northeastern China in 2007. Virus Genes. 2011 Dec;43(3):342–9. doi: 10.1007/s11262-011-0642-4. 参考文献:10.1371/journal.pbio.1001099 摘要:Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidißel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Schöler HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011 Jul 12;9(7):e1001099. doi: 10.1371/journal.pbio.1001099. 参考文献:10.1007/s00428-005-0105-1 摘要:Heiskala K, Giles-Komar J, Heiskala M, Andersson LC. High expression of RELP (Reg IV) in neoplastic goblet cells of appendiceal mucinous cystadenoma and pseudomyxoma peritonei. Virchows Arch. 2006 Mar;448(3):295–300. doi: 10.1007/s00428-005-0105-1.