CAS: 1270138-41-4; (4-Benzylpiperazin-1-yl)(2-(Isopentylamino)Pyridin-3-yl)Methanone Phosphate

英文名称(4-Benzylpiperazin-1-yl)(2-(Isopentylamino)Pyridin-3-yl)Methanone Phosphate
中文名称NSI-189磷酸盐
IUPAC名称(4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone phosphate
其它别名(4-Benzylpiperazin-1-yl)-[2-(3-Methylbutylamino)Pyridin-3-Yl]Methanone,Phosphoric Acid
CAS编号1270138-41-4
MFCD编号:MFCD30718750
FDA UNII编号:HX0VO60T62
分子式:C22H33N4O5P分子量:464.5
产品CID: 429354
同类组份化合物CAS1270138-40-3 (free base)1270138-41-4 (phosphate)
产品分类有机原料 → 羧酸类化合物及衍生物

相似结构搜索
InChIKey: LWHMGALTTIYPJU-UHFFFAOYSA-N
InChI=1S/C22H30N4O.H3O4P/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19;1-5(2,3)4/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24);(H3,1,2,3,4)
计算化学: 氢键受体数8.0氢键供体数4.0可旋转键数7.0

物理性质

外观形态固体-粉末
储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

MSDS等安全信息

合成工艺路线路线简述

📜[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮以79的收率获得nsi-189磷酸盐
参考文献:Synthesis Of A Neurostimulative Piperazine
标题:Synthesis Of A Neurostimulative Piperazine
摘要:该发明描述了一种改进的合成方法,用于合成与烟酸和苄基衍生的哌嗪.产品化合物可用于治疗神经系统疾病.

海关参考信息

2902300000-甲苯
2912110000-甲醛
2921211000-乙二胺
2924191000-二甲基甲酰胺
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详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: McIntyre RS, Johe K, Rong C, Lee Y. The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects. Expert Opin Investig Drugs. 2017 Jun;26(6):767-770. doi: 10.1080/13543784.2017.1324847. Epub 2017 May 8. 32(3):182-196. 232(10):2731-2740. doi: 10.1002/jcp.25847. Epub 2017 Apr 25.
4: Jolivalt CG, Aghanoori MR, Navarro-Diaz MC, Han MM, Sanchez G, Guernsey L, Quach D, Johe K, Fernyhough P, Calcutt NA. Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes. J Diabetes Res. 2022 Jul 4;2022:8566970. doi: 10.1155/2022/8566970.
5: Liu Y, Johe K, Sun J, Hao X, Wang Y, Bi X, Baudry M. Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189. Neuropharmacology. 2019 Jan;144:337-344. doi: 10.1016/j.neuropharm.2018.10.038. Epub 2018 Nov 5. 68(11):2143-2154. doi: 10.2337/db19-0271. Epub 2019 Sep 6.