CAS: 1239-31-2; Epiandrosterone Acetate

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CAS号481-29-8 表雄酮 | CAS号108-24-7 乙酸酐 | CAS号23498-55-7 Androstan-17-on... | CAS号20120-08-5 androsterone | CAS号1080507-42-1 5β-pregnene-(17... | CAS号64-19-7 冰醋酸 | CAS号23017-29-0 Pregn-17(20)-en... | CAS号481-29-8 表雄酮 | CAS号2429-15-4 Androst-9(11)-e... | CAS号846-46-8 5a-雄甾烷二酮 | CAS号53-41-8 雄酮 | CAS号571-20-0 5α-雄烷二醇 | CAS号1247-67-2 Androst-16-ene-... | CAS号59981-94-1 Androstane-3,11... | CAS号51773-60-5 Androstan-3-one...

醋酸去氢表雄酮置于palladium 10% On Activated Carbon,氢气体系中,用 乙醇 用作溶剂,化学反应 18.0H,以75%的收率获得醋酸去氢表雄酮
参考文献:人类长期羟甲烯龙代谢物的合成
标题:人类长期羟甲烯龙代谢物的合成
摘要:已通过 Gc-Ms/ms 鉴定的掺杂剂羟甲烯龙 (Oxm-M2,17β-Hydroxymethyl-2,17α-Methyl-18-Norandrost-13-En-3-One) 的长期代谢物合成自市售材料.开发了两种有效的合成路线,以获取两种暂定代谢物的 C-17 差向异构体.体内代谢物的身份和分子构型:17β-羟甲基-2α,17α-甲基-18-Norandrost-13-En-3-One 由单晶 X 射线衍射证实.
Doi:10.1016/j.Steroids.2019.108430

专利信息

专利号:US-9884067-B2
优先权日:2013-03-14
标 题:Androgen receptor down-regulating agents and uses thereof
发明人：NJAR VINCENT C O; GEDIYA LALJI K; PURUSHOTTAMACHAR PURANIK; GODBOLE ABHIJIT; KWEGYIR AFFUL ANDREW; VASAITIS TADAS
权利人:UNIV OF MARYLAND EASTERN SHORE; UNIV JEFFERSON; UNIV MARYLAND
摘要:The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.