CAS: 1197-10-0; 6-(Hydroxymethyl)Picolinic Acid

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上下游产品

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吡啶-2.6-二羧酸二甲酯置于sodium Tetrahydroborate,水,Sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 3.17H,反应生成6-羧基吡啶-2-甲醇
参考文献:糖基转移酶抑制剂的设计:吡啶作为焦磷酸盐的替代物
标题:糖基转移酶抑制剂的设计:吡啶作为焦磷酸盐的替代物
摘要:通过使用吡啶作为焦磷酸盐替代物,已经设计并合成了一系列十种糖基转移酶抑制剂.该系列是通过结合糖基化,Staudinger-Vilarrasa酰胺键形成和叠氮化物-炔烃点击化学反应,结合碳水化合物,吡啶和核苷结构单元而制备的.该化合物被评估为五种金属依赖性半乳糖基转移酶的抑制剂.三种酶在一种酶的活性位点复合的抑制剂的晶体学分析证实,吡啶部分螯合了mn 2+离子,导致其原始位置略微移位(2å).与天然尿苷二磷酸(udp)-Gal底物相比,碳水化合物的头基占据的位置不同,与酶的相互作用很小.
Doi:10.1002/chem.201301871

专利信息

专利号:US-6875774-B2
优先权日:2002-08-06
标题:Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands
发明人：KOHN HAROLD; HARDEN T KENDALL; KIM MYOUNG GOO; BODOR ERIK
权利人:UNIV NORTH CAROLINA
摘要:The present invention discloses novel cholinergic receptor ligands. The present invention also relates to the synthesis of substituted derivatives of aza-bridged bicyclic amines for use as muscarinic receptor ligands as well as methods of regulating function of certain cholinergic receptors, and hence acting as antagonists, agonists and partial agonists at certain specific cholinergic receptor subtypes. The present invention also relates to methods for treating disorders associated with cholinergic receptors.