合成目标产物 N-Carbamyl-L-Glutamic Acid 主要起始原料 L-Glutamic Acid And Sodium Cyanate
(文献来源)合成步骤主要原料 L-Glutamic Acid 和 Sodium Cyanate
Carglumic Acid Lithium Salt置于盐酸体系中,用 水 用作溶剂,以99%的收率获得n-氨基甲酰-L-谷氨酸 参考文献: Process For The Synthesis Of Carglumic Acid[fr] Procédé De Synthèse D'Acide Carglumique 标题: Process For The Synthesis Of Carglumic Acid[fr] Procédé De Synthèse D'Acide Carglumique 摘要:该发明涉及一种从l-谷氨酸和氰酸钠经过在水性介质中与锂化合物处理合成卡古酸的过程.根据该发明的工艺容易实现工业化规模化,并且比已知的程序更快,更便宜.公式(i)
专利号:WO-2011160259-A1 优先权日:2010-06-24 标题 :Use of n-carbamoyl glutamic acid, salts or esters thereof in manufacture of health care products for protecting liver or promoting muscle growth 发明人:HU CHANGCHUN 权利人:SHANGHAI YONG YI BIOTECHNOLOGY CO LTD; HU CHANGCHUN 摘要:Use of N-carbamyl glutamic acid, salts or esters thereof in the manufacture of health care products for protecting liver or promoting muscle growth is provided in the present invention. N-carbamoyl glutamic acid can prevent and treat hyperazotemia, a liver cirrhosis complication, through increasing urea cycle in liver, and increase synthesis of arginine in the body, promote synthesis of proteins and muscle growth in low dose. Amino acids compositions and health care products for protecting liver or promoting muscle growth, consisting of N-carbamoyl glutamic acid, salts or esters thereof, arginine, salts or esters thereof, pyridoxine hydrochloride, glycine, compounds containing zinc, micotinamide, taurine, and succinic acid are also provided in the present invention.
专利号:US-2024400861-A1 优先权日:2021-10-01 标题 :Triazole- And/Or Triazolium-Based Polymers And Copolymers As Additives For Chemical Mechanical Planarization Slurries 发明人:LARBIG GREGOR; KIRSCH PEER; HENGST MATTHIAS; SHI XIAOBO; STENDER MATTHIAS 权利人:VERSUM MAT US LLC 摘要:Synthesis of triazole- and/or triazolium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising triazole- and/or triazolium-based polymers; and water. The use of the synthesized triazole- and/or triazolium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.
专利号:IT-201800009372-A1 优先权日:2018-10-11 标题:PROCESS FOR THE SYNTHESIS OF CARGLUMIC ACID
专利号:CN-116438165-A 优先权日:2020-11-19 标 题:Synthesis of Prostate Specific Membrane Antigen (PSMA) ligands
专利号:WO-2025038979-A1 优先权日:2023-08-16 标 题:Compositions and methods for prophylaxis and/or treatment of amyloid b peptide proteinopenia in alzheimer's and other diseases 发明人:LEE JIN HYUNG; AHMED KARIEM E; ANDALOUSSI SAMIR EL 权利人:LVIS REGAIN LP 摘要:Material compositions and/or methods useful for the prophylaxis and/or treatment of protein depletion (proteinopenia) are provided, including material compositions that retains native function of a peptide/protein while limiting and/or preventing amyloid formation and/or aggregation of said peptide/protein. Material compositions and formulations for enhancing peptide/protein solubility, stability, circulation time, receptor interaction, brain penetrance, CSF half-life, facilitating peptide/protein synthesis and purification are also provided.
专利号:WO-2024073211-A1 优先权日:2022-09-29 标题:Guanidinium-based polyionic liquids and their use as additives for chemical mechanical planarization slurries 发明人:LARBIG GREGOR; KIRSCH PEER; SHI XIAOBO 权利人:VERSUM MAT US LLC 摘要:Synthesis of guanidinium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising guanidinium-based polymers; and water. The use of the synthesized guanidinium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.
1: Matoori S, Leroux JC. Recent advances in the treatment of hyperammonemia. Adv Drug Deliv Rev. 2015 Aug 1;90:55-68. doi: 10.1016/j.addr.2015.04.009. Epub 2015 Apr 17. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK284774/
合成参考文献
参考文献:10.1203/00006450-200109000-00010 摘要:De Lonlay P, Benelli C, Fouque F, Ganguly A, Aral B, Dionisi-Vici C, Touati G, Heinrichs C, Rabier D, Kamoun P, Robert JJ, Stanley C, Saudubray JM. Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients. Pediatr Res. 2001 Sep;50(3):353–7. doi: 10.1203/00006450-200109000-00010. 参考文献:10.1177/2168479017720248 摘要:Kondo H, Saint-Raymond A, Yasuda N. What to Know About Medicines With New Active Ingredients Approved in FY 2016 / 2016 in Japan and EU: A Brief Comparison of New Medicines Approved in Japan and the EU in 2016. Ther Innov Regul Sci. 2018 Mar;52(2):214–9. doi: 10.1177/2168479017720248.