CAS: 1119-65-9; 2-Heptyne

相似化合物

1942-46-7 6975-99-1 20184-89-8

上下游产品

1-Heptyne 1-bromo-2-heptyne hexenylmagnesium bromide dimethyl sulfate n-pentyl methyl ketone (Z)-hept-2-ene heptan-3-one 2-methylhexanoic acid

📜2-Butyl-3-Methylcyclopropenone 以 甲醇 用作溶剂,化学反应生成2-庚炔
参考文献:高效的三键光化学生成:环戊烯酮的合成,性质和光脱羰基.
标题:高效的三键光化学生成:环戊烯酮的合成,性质和光脱羰基.
摘要:烷基,芳基和杂原子取代的环丙烯酮的uv照射导致一氧化碳损失并形成相应炔烃的定量收率.光化学脱羰反应的量子产率从烷基取代的环丙烯酮的20%到30%到二苯基和二萘基环戊烯酮的70%以上.通过使用激光闪光光解法观测到该反应中中间体迅速形成(<5 Ns),然后稍微慢一些(约40 Ns)衰变.Dft计算使我们能够将这种中间体鉴定为由环丙烯酮环的碳-碳键之一裂解形成的两性离子物质.后者然后迅速损失一氧化碳以产生最终的炔属产物.尽管它们的光反应性很高,除羟基和甲氧基取代的环丙烯酮外,发现环丙烯酮是热稳定的化合物.后者甚至在室温下也能在羟基溶剂中进行快速溶剂分解.该反应对苯二炔结构原位生成的应用通过苯并二烯化的苯二炔12的光化学制备进行了说明.
Doi:10.1021/jo034869M

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-2007049757-A1
优先权日:2005-08-26
标题:Methods for the synthesis of substituted amino uracils
发明人：RIEGER JAYSON M; THOMPSON ROBERT
权利人:RIEGER JAYSON M; THOMPSON ROBERT
摘要:The invention provides novel methods of preparing substituted amino uracil compounds that can be employed as useful intermediates in the synthesis of various xanthines. Highly regioselective unsymmetrical amino uracils can be obtained using these methods which is a particular advantage over other existing methods.

专利号:US-10538790-B2
优先权日:2016-04-04
标题 :Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents
发明人：KAVARANA MALCOLM J; PEET RICHARD C
权利人:TEEWINOT TECH LIMITED
摘要:The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:US-9988349-B2
优先权日:2014-01-03
标 题:Direct stereospecific synthesis of unprotected aziridines from olefins
发明人：ESS DANIEL HALSELL; FALCK JOHN RUSSELL; JAT JAWAHAR LAL; KURTI LASZLO
权利人:ESS DANIEL HALSELL; FALCK JOHN RUSSELL; JAT JAWAHAR LAL; KURTI LASZLO
摘要:A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N—H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal catalyst. The method is operationally simple (i.e., one-pot), scalable and fast at ambient temperature.