
专利信息
专利号:EP-1363951-B1
优先权日:2000-12-07
标 题 :Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex
发明人:ILIC LJUBOMIR; RISTIC SUZANA; CAKIC MILORAD; NIKOLIC GORAN; STANKOVIC SLOBODAN
权利人:AD ZDRAVLJE FARMACEUTSKO HEMIJ
摘要:A polynuclear complex of pullulan oligomers of formula (I): wherein n = (100-8200), obtained by process of synthesis of soluble pullulan with insoluble iron (III)-hydroxyde of formula (II): wherein n=(900). The process of synthesis is characterized by technical simplicity and economy. In accordance with suggested process, first of all, preparation of pullulan for synthesis, including its characterization (determination of RG, Mw, Mn, [θ]) is carried out, and subsequently its hydrogenation is carried out in order to eliminate reducing groups, iron(III)-hydroxyde gel is prepared, and synthesis of the complex can start. Obtained complex is afterwards prepared for pharmacological use and it is subjected to the subsequent physical and chemical processes of purification. The preparation obtained in such a way is used for prevention and treatment of syderopenic anemia in human and veterinay medicine.
专利号:US-2024285670-A1
优先权日:2021-06-11
标题 :Therapeutic treatment of tumors by blocking the heme synthesis-export axis
发明人:TOLOSANO EMANUELA; FIORITO VERONICA; PETRILLO SARA; CHIABRANDO DEBORAH; ALLOCCO ANNA LUCIA; BERTINO FRANCESCA
权利人:UNIV DEGLI STUDI DI TORINO
摘要:A blocker of heme synthesis-export axis as active agent for use in the treatment of a tumor in a subject, wherein the blocker of heme synthesis-export axis upmodulates oxidative metabolism of tumor cells by upregulating the tricarboxylic acid (TCA) cycle and the oxidative phosphorylation (OXPHOS).
专利号:CN-117361562-A
优先权日:2023-10-24
标 题 :Crystallization synthesis of a high-content framework iron ZSM-35 molecular sieve
专利号:WO-2022259144-A1
优先权日:2021-06-11
标 题:Therapeutic treatment of tumors by blocking the heme synthesis-export axis
专利号:EP-4351555-A1
优先权日:2021-06-11
标 题:Therapeutic treatment of tumors by blocking the heme synthesis-export axis
专利号:IT-202100015368-A1
优先权日:2021-06-11
标 题:THERAPEUTIC TREATMENT OF CANCER THROUGH BLOCK OF THE HEME SYNTHESIS-EXPORT AXIS