CAS: 949-90-6; Benzyl (2-Amino-2-Oxoethyl)Carbamate

该化合物是一种在农业和虫害控制中应用多种的氨基甲酸酯杀虫剂,其特点是能够抑制酶乙酰胆碱酯酶,导致突变裂端中乙酰胆碱酯酶的累积,这扰乱了害虫的正常...

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CAS号501-53-1 氯甲酸苄酯 | CAS号598-41-4 甘氨酰胺 | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号108849-83-8 methyl Z-glycyl... | CAS号41961-03-9 Cbz-Gly-L-Thr-OMe | CAS号1212-53-9 CBZ-甘氨酸甲酯 | CAS号137862-14-7 hex-1-en-2-yl 2... | CAS号121611-58-3 prop-1-en-2-yl ... | CAS号1145-81-9 N-Cbz-甘氨酸乙酯 | CAS号49548-40-5 N-苄氧甲酰甘氨酸硫代酰胺 | CAS号3589-41-1 N-(苄氧羰基)氨基乙腈 | CAS号72080-83-2 N-Cbz-1,,2-二氨基乙烷 | CAS号91641-80-4 ETHANETHIOIC AC... | CAS号62076-55-5 2-Propenoic aci... | CAS号63808-38-8 Glycine, N-[1-i...

合成工艺路线路线简述

  • 合成目标产物 Z-Gly-Nh2 主要起始原料 Glycinamide Hydrochloride And Benzyl Chloroformate
  • 201297-38-3 = 949-90-6
    反应条件:1.1 Reagents: Dimethylamine Solvents: Methanol
    标题:Synthesis And Characterization Of B-O-Tosyldehydroserine As A Precursor Of Dehydroamino Acids
    作者:Nakazawa,Takashi; Susuki,Tomiko; Ishii,Masako
    参考文献:Tetrahedron Letters 日期:1997 卷标:38(52) 页码:8951-8954]

    598-41-4 = 949-90-6
    反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: 1,4-Dioxane,Water
    标题:Total Synthesis Of Nosiheptide. Synthesis Of Thiazole Fragments
    作者:Koerber-Ple,Karen; Massiot,Georges
    参考文献:Journal Of Heterocyclic Chemistry 日期:1995 卷标:32(4) 页码:1309-15]

    598-41-4 = 949-90-6
    反应条件:1.1 Solvents: 1,4-Dioxane,Water; Cooled; Rt; 12 H,Rt
    标题:Pyrimidine-4-Carboxamide Compounds Useful As Raf Kinase Inhibitors And Their Preparation And Use In The Treatment Of Raf-Mediated Diseases
    参考文献:World Intellectual Property Organization]

    598-41-4 = 949-90-6
    反应条件:1.1 Solvents: 1,4-Dioxane,Water; Cooled; Rt; 12 H,Rt
    标题:Heterocyclic Compounds Useful As Raf Kinase Inhibitors And Their Preparation,And Use In The Treatment Of Raf-Mediated Diseases
    参考文献:United States]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Pyridine,Ammonium Bicarbonate,Di-Tert-Butyl Dicarbonate Solvents: Dimethylformamide
    标题:Activation Of Carboxylic Acids By Pyrocarbonates. Application Of Di-Tert-Butyl Pyrocarbonate As Condensing Reagent In The Synthesis Of Amides Of Protected Amino Acids And Peptides
    作者:Pozdnev,Vladimir F.
    参考文献:Tetrahedron Letters 日期:1995 卷标:36(39) 页码:7115-18]

    1738-86-9 = 949-90-6
    反应条件:1.1 Reagents: Ammonia Solvents: Methanol
    标题:Synthesis Of Arginine-Containing Peptides Through Their Omithine Analogs. Synthesis Of Arginine Vasopressin,Arginine Vasotocin,And L-Histidyl-L-Phenylalanyl-L-Arginyl-L-Tryptoph-Ylglycine
    作者:Bodanszky,Miklos; Ondetti,Miguel A.; Birkhimer,Carolyn A.; Thomas,Patsy L.
    参考文献:Journal Of The American Chemical Society 日期:1964 卷标:86(20) 页码:4452-9]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Ammonium Benzoate Catalysts: Triacylglycerol Lipase Solvents: Toluene; 16 H,50 °C
    标题:Enzymatic C-Terminal Amidation Of Amino Acids And Peptides
    作者:Nuijens,Timo; Piva,Elena; Kruijtzer,John A. W.; Rijkers,Dirk T. S.; Liskamp,Rob M. J.; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(29) 页码:3777-3779]

    1212-53-9 = 949-90-6
    反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Water
    标题:Inverse Electron Demand Diels-Alder Reactions Of Indole. Iv. A New Route To β-Carbolines
    作者:Fan,Wen-Hong; Parikh,Mamta; Snyder,John K.
    参考文献:Tetrahedron Letters 日期:1995 卷标:36(37) 页码:6591-4]

    3589-41-1 = 949-90-6
    反应条件:1.1 Reagents: Water Catalysts: Ruthenium (Supported On Chitin),Chitosan; 16 H,120 °C
    标题:Hydration Of Nitriles To Amides By A Chitin-Supported Ruthenium Catalyst
    作者:Matsuoka,Aki; Isogawa,Takahiro; Morioka,Yuna; Knappett,Benjamin R.; Wheatley,Andrew E. H.; Et Al
    参考文献:Rsc Advances 日期:2015 卷标:5(16) 页码:12152-12160]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: 4-Methylmorpholine,Isobutyl Chloroformate Solvents: Tetrahydrofuran; 2 Min,-20 °C; 15 Min,0 °C1.2 Reagents: Ammonia Solvents: Water; 1 H,0 °C
    标题:Polythiazole Linkers As Functional Rigid Connectors: A New Rgd Cyclopeptide With Enhanced Integrin Selectivity
    作者:Ruiz-Rodriguez,J.; Miguel,M.; Preciado,S.; Acosta,G. A.; Adan,J.; Et Al
    参考文献:Chemical Science 日期:2014 卷标:5(10) 页码:3929-3935]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: 4-Methylmorpholine,Isobutyl Chloroformate,Ammonia Solvents: Water
    标题:Preparation Of Cyclic Rgd Peptides Of Amino Acids Based On Thiazoles Or Oxazoles As Selective Antagonists Of αvβ3 Integrin
    参考文献:World Intellectual Property Organization]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Methyl Iodide,Sodium Carbonate Solvents: Dimethylformamide; Rt; 24 H,Rt1.2 Reagents: Ammonium Hydroxide Solvents: Tetrahydrofuran; 24 H,Rt
    标题:Parallel Synthesis Of An Oligomeric Imidazole-4,5-Dicarboxamide Library
    作者:Xu,Zhigang; Dicesare,John C.; Baures,Paul W.
    参考文献:Journal Of Combinatorial Chemistry 日期:2010 卷标:12(2) 页码:248-254]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide,Dichloromethane1.2 Reagents: Ammonia Solvents: Dimethylformamide,Dichloromethane,Water
    标题:A Simple Method For Amide Formation From Protected Amino Acids And Peptides
    作者:Chen,Shui Tein; Wu,Shih Hsiung; Wang,Kung Tsung
    参考文献:Synthesis 日期:1989 卷标:(1) 页码:37-8]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Triethylamine,Ethyl Chloroformate Solvents: Tetrahydrofuran; -10 °C; 30 Min,-10 °C1.2 Reagents: Ammonia Solvents: Water; 45 Min,-10 °C
    标题:N-Alkenylation Of Hydroxamic Acid Derivatives With Ethynyl Benziodoxolone To Synthesize Cis-Enamides Through Vinyl Benziodoxolones
    作者:Shimbo,Daisuke; Maruyama,Toshifumi; Tada,Norihiro; Itoh,Akichika
    参考文献:Organic & Biomolecular Chemistry 日期:2021 卷标:19(11) 页码:2442-2447]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 5 Min,0 °C1.2 Reagents: Ethyl Chloroformate; 15 Min,0 °C1.3 Reagents: Ammonia; 1 H,Rt
    标题:Urea Derivatives As Pyruvate Kinase Activators And Their Preparation
    参考文献:World Intellectual Property Organization]

    1668-10-6 = 949-90-6
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Acetone,Water; Ph 8,0 °C1.2 0 °C; 2 H,Rt
    标题:Antibody Drug Conjugate Containing Sn38 And Its Application In Cancer And Autoimmune Disease
    参考文献:China]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Triethylamine,Ethyl Chloroformate1.2 Reagents: Ammonia Solvents: Water
    标题:Convenient Synthesis Of Phosphonodipeptides Containing C-Terminal α-Aminoalkylphosphonic Acids
    作者:Sun,Biyun; Xu,Jiaxi
    参考文献:Journal Of Peptide Science 日期:2015 卷标:21(7) 页码:615-619]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: 4-Methylmorpholine,Ethyl Chloroformate Solvents: Tetrahydrofuran; 20 Min,-15 °C1.2 Reagents: Ammonia Solvents: Water; 4 H,-15 °C
    标题:One-Pot Synthesis Of Orthogonally Protected Dipeptide Selenazoles Employing Nα-Amino Selenocarboxamides And α-Bromomethyl Ketones
    作者:Madhu,Chilakapati; Panguluri,Nageswara Rao; Narendra,N.; Panduranga,V.; Sureshbabu,Vommina V.
    参考文献:Tetrahedron Letters 日期:2014 卷标:55(50) 页码:6831-6835]

    1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Triethylamine,Ethyl Chloroformate Solvents: Tetrahydrofuran; 0 °C; 30 Min,0 °C1.2 Reagents: Ammonia; 30 Min,0 °C
    标题:Direct Synthesis Of Phosphinopeptides Containing C-Terminal α-Aminoalkylphosphinic Acids
    作者:Meng,Fan-Hua; Xu,Jia-Xi
    参考文献:Amino Acids 日期:2010 卷标:39(2) 页码:533-538]

    3899-07-8 + 1138-80-3 = 949-90-6
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide,N-Hydroxysuccinimide Solvents: Acetonitrile1.2 Solvents: Acetonitrile
    标题:Structure-Activity Relationships Of Dopaminergic 5-Hydroxy-2-Aminotetralin Derivatives With Functionalized N-Alkyl Substituents
    作者:Seiler,Max P.; Stoll,Andre P.; Closse,Annemarie; Frick,Willy; Jaton,Annelise; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1986 卷标:29(6) 页码:912-17
1,4-Bis-Chloroacetyl-Piperazine-2,5-Dione置于氨体系中,化学反应生成 N-苄氧羰基甘氨酰胺
参考文献:Lerman; Gawrilow,Zhurnal Obshchei Khimii,1941,Vol. 11,P. 127,131
标题:Lerman; Gawrilow,Zhurnal Obshchei Khimii,1941,Vol. 11,P. 127,131

海关参考信息

专利信息


专利号:US-RE29669-E
优先权日:1973-04-23
标 题:Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.

专利号:US-3725380-A
优先权日:1969-04-05
标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
发明人：KONIG W; GEIGER R
权利人:HOECHST AG
摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

专利号:US-3795666-A
优先权日:1969-08-01
标 题 :Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine
发明人：KONIG W; GEIGER R; WOLF E
权利人:HOECHST AG
摘要:IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

专利号:US-3971802-A
优先权日:1974-04-19
标题 :Certain N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)-N-(2-thiazolyl)glycineamides
发明人：LOMBARDINO JOSEPH G
权利人:PFIZER
摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.

专利号:US-3954786-A
优先权日:1974-04-19
标 题 :Isoxazole intermediate compounds
发明人：LOMBARDINO JOSEPH G
权利人:PFIZER
摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150°C., said products being antiinflammatory agents.

专利号:US-3927002-A
优先权日:1973-04-23
标题:N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
发明人：LOMBARDINO JOSEPH G
权利人:PFIZER
摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N''-alkyl-N''-(2''alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50*-150* C., said products being antiinflammatory agents.

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主要参考文献

参考标题:A New Approach To Peptide Synthesis
作者:Christopher J. Moody,Elizabeth Swann,Christopher J. Moody,Leigh Ferris,David Haigh
摘要:A New Approach To The Synthesis Of Dipeptides Is Described Based On The Formation Of The Nhchr1Conh-Chr2Co Bond By Carbenoid N-H Insertion, Rather Than The Formation Of The Peptide Bond Itself.

合成参考文献


摘要:Virieux, D.; Ayad, T.; Pirat, J.-L.; Volle, J.-N., Science of Synthesis Knowledge Updates, (2018) 1, 276.
摘要:Xu, C.; Shao, X.; Shen, Q., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 48.
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