CAS: 90-47-1; 9H-Xanthen-9-One

该化合物是属于多环芳烃类的有机化合物,具有三环结构,由含有碳基的中Xanthene核心组成,具有独特的化学特性.Xanthone的典型特征是黄色晶状,在乙醇和丙酮等有机溶剂中可溶解,但水溶解性有限.该化合物展示了有趣的光物理特性,包括荧光,使其在包括染料,色素在内的各种应用中具有价值,并作为生物化学研究中的荧光探针探针.此外,对Xanthone及其衍生物的潜在生物活动进行了研究,包括抗氧化剂,抗炎和抗微生物特性.其活性允许各种化学改变,导致各种衍生物的增强或改变.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号88284-48-4 2-(三甲基硅)苯基三氟甲烷磺酸盐 | CAS号445-29-4 邻氟苯甲酸 | CAS号92-83-1 氧杂蒽 | CAS号82-07-5 呫吨-9-羧酸 | CAS号1304461-08-2 4-methyl-N-(2-p... | CAS号88-67-5 邻碘苯甲酸 | CAS号118-91-2 邻氯苯甲酸 | CAS号118-55-8 水杨酸苯酯 | CAS号76279-43-1 N,N-diethyl-2-p... | CAS号19434-34-5 2-苯氧基苯甲醛 | CAS号92-83-1 氧杂蒽 | CAS号90-46-0 占吨氢醇 | CAS号117-99-7 2-羟基二苯甲酮 | CAS号517-45-3 9,9'-二亚呫吨 | CAS号4381-14-0 9-(9H-xanthen-9... | CAS号27265-96-9 9-(diphenylmeth... | CAS号632-51-9 1,1,2,2-四苯乙烯 | CAS号6538-19-8 dixanthyl ether | CAS号21147-18-2 (2-hydroxypheny... | CAS号120-51-4 苯甲酸苄酯

合成工艺路线路线简述

  • 合成目标产物 Xanthone 主要起始原料 2-Bromofluorobenzene And Salicylaldehyde
  • 92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Catalysts: 2808473-59-6 Solvents: Acetonitrile; 16 H,65 °C
    标题:Highly Efficient Multi-Site Synergistic Catalysis Of A Polyoxovanadate-Based Metal-Organic Framework For Benzylic C-H Bond Oxidation
    作者:Dang,Tian-Yi; Li,Run-Han; Tian,Hong-Rui; Guan,Wei; Lu,Ying; Et Al
    参考文献:Journal Of Materials Chemistry A: Materials For Energy And Sustainability 日期:2022 卷标:10(31) 页码:16514-16523]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Stereoisomer Of [[n′′,N′′′′′,N′′′′′′′′-[(Nitrilo-Kn)Tri-2,1-Ethanediyl]Tris[n,N,... Solvents: Acetone; 0 °C
    标题:Formation Of Cobalt-Oxygen Intermediates By Dioxygen Activation At A Mononuclear Nonheme Cobalt(Ii) Center
    作者:Malik,Deesha D.; Chandra,Anirban; Seo,Mi Sook; Lee,Yong-Min; Farquhar,Erik R.; Et Al
    参考文献:Dalton Transactions 日期:2021 卷标:50(34) 页码:11889-11898]

    90-46-0 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Methanesulfinic Acid,1,1,1-Trifluoro-,Sodium Salt (1:1) Solvents: Acetonitrile; 12 H,1 Atm,25 °C
    标题:A Sodium Trifluoromethanesulfinate-Mediated Photocatalytic Strategy For Aerobic Oxidation Of Alcohols
    作者:Zhu,Xianjin; Liu,Can; Liu,Yong; Yang,Haijun; Fu,Hua
    参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(82) 页码:12443-12446]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Catalysts: Benzyltriethylammonium Chloride Solvents: Dichloromethane
    标题:Oxidation Of Benzyl Ethers Via Phase Transfer Catalysis
    作者:Markgraf,J. Hodge; Choi,Bo Yoon
    参考文献:Synthetic Communications 日期:1999 卷标:29(14) 页码:2405-2411]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,2,3,4,5,6-Pentafluorobenzeneseleninic Acid Solvents: Benzene
    标题:Novel Allylic Oxidation Reagents
    作者:Barton,Derek H. R.; Wang,Tie-Lin
    参考文献:Tetrahedron Letters 日期:1994 卷标:35(29) 页码:5149-52]

    492-21-7 = 90-47-1
    反应条件:1.1 Reagents: Cuprous Chloride Solvents: Acetonitrile1.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Thiocarbonyl To Carbonyl Group Transformation Using Cuprous Chloride And Sodium Hydroxide
    作者:Narasimhamurthy,N.; Samuelson,A. G.
    参考文献:Tetrahedron Letters 日期:1986 卷标:27(33) 页码:3911-12]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Riboflavin,2′,3′,4′,5′-Tetraacetate Solvents: Acetonitrile; 8 H,1 Atm,Rt
    标题:Synthesis Of Xanthones,Thioxanthones And Acridones By A Metal-Free Photocatalytic Oxidation Using Visible Light And Molecular Oxygen
    作者:Torregrosa-Chinillach,Alejandro; Chinchilla,Rafael
    参考文献:Molecules 日期:2021 卷标:26(4)]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Acetic Acid,2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone,Tert-Butyl Nitrite Solvents: 1,2-Dichloroethane; 12 H,Rt
    标题:Visible-Light-Induced Aerobic Oxidation Of Benzylic C(Sp 3 )-H Of Alkylarenes Promoted By Ddq,Tert -Butyl Nitrite,And Acetic Acid
    作者:Pan,Decheng; Wang,Yiqing; Li,Meichao; Hu,Xinquan; Sun,Nan; Et Al
    参考文献:Synlett 日期:2019 卷标:30(2) 页码:218-224]

    90-46-0 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Cesium,(Tribromoplumbyl)- Solvents: Dichloromethane; 2.5 H,Rt
    标题:Visible-Light Photocatalytic Highly Selective Oxidation Of Alcohols Into Carbonyl Compounds By Cspbbr3 Perovskite
    作者:Fan,Qiangwen; Liu,Dawei; Xie,Zongbo; Le,Zhanggao; Zhu,Haibo; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(20) 页码:14559-14570]

    2243-42-7 = 90-47-1 [标题:Reaction Conditions
    标题:Cyclodehydration Reactions Using Molten Sodium Tetrachloroaluminate
    作者:Wade,L. G. Jr.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1979 卷标:44(21) 页码:3724-5]

    82-07-5 = 90-47-1
    反应条件:1.1 Reagents: Lithium Chloride,Oxygen Catalysts: Copper Chloride Dihydrate Solvents: Acetonitrile; 48 H,25 °C
    标题:Visible Light-Driven Copper(Ii) Catalyzed Aerobic Oxidative Cleavage Of Carbon-Carbon Bonds: A Combined Experimental And Theoretical Study
    作者:Li,Sanliang; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2022 卷标:9(22) 页码:6229-6239]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: Tempol,Iron Nitrate (Fe(No3)3) Nonahydrate Solvents: Acetonitrile; 37 H,25 °C
    标题:Iron Nitrate And 4-Oh-Tempo-Cocatalyzed Aerobic Oxidation Of Isochromans
    作者:Zhang,Qian; Zhang,Jiabin; Qian,Hui; Ma,Shengming
    参考文献:Organic Chemistry Frontiers 日期:2023 卷标:10(6) 页码:1505-1511]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Hydrogen Catalysts: Pyridinium,4,4′,4′′-(1,3,5-Triazine-2,4,6-Triyl)Tris[1-Ethyl-,Bromide (1:3) Solvents: Acetonitrile; 18 H,Rt
    标题:Redox-Active And Bronsted Basic Dual Sites For Photocatalytic Activation Of Benzylic C-H Bonds Based On Pyridinium Derivatives
    作者:Ma,Shuai; Ma,Jin-Ming; Cui,Jing-Wang; Rao,Cai-Hui; Jia,Meng-Ze; Et Al
    参考文献:Green Chemistry 日期:2022 卷标:24(6) 页码:2492-2498]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Peracetic Acid Catalysts: 2479278-27-6 Solvents: Acetic Acid,Acetonitrile; 24 H,60 °C
    标题:Palladium Aminopyridine Complexes Catalyzed Selective Benzylic C-H Oxidations With Peracetic Acid
    作者:Lubov,Dmitry P.; Lyakin,Oleg Yu.; Samsonenko,Denis G.; Rybalova,Tatyana V.; Talsi,Evgenii P.; Et Al
    参考文献:Dalton Transactions 日期:2020 卷标:49(32) 页码:11150-11156]

    90-46-0 = 90-47-1
    反应条件:1.1 Reagents: Oxygen Catalysts: 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone,Nitric Acid Solvents: Dichloromethane; 18 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:Scalable Aerobic Oxidation Of Alcohols Using Catalytic Ddq/hno3
    作者:Katsina,Tania; Clavier,Louis; Giffard,Jean-Francois; Macedo Portela Da Silva,Nayane; Fournier,Jean; Et Al
    参考文献:Organic Process Research & Development 日期:2020 卷标:24(5) 页码:856-860]

    21905-56-6 = 90-47-1
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: 1,2-Dichloroethane; 12 H,130 °C
    标题:Concise Synthesis Of Xanthones By The Tandem Etherification-Acylation Of Diaryliodonium Salts With Salicylates
    作者:Liu,Gaoxiaozheng; Wu,Chao; Chen,Bifeng; He,Ru; Chen,Chao
    参考文献:Chinese Chemical Letters 日期:2018 卷标:29(6) 页码:985-988]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Catalysts: Manganese Oxide (Mno2) Solvents: Acetonitrile,Water; 10 H,80 °C
    标题:Oxidation Of Alkyl Aromatics To Ketones By Tert-Butyl Hydroperoxide On Manganese Dioxide Catalyst
    作者:Burange,Anand S.; Kale,Sandip R.; Jayaram,Radha V.
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(24) 页码:2989-2992]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1),Manganese Sulfate Hydrate (Solid Support) Solvents: Dichloromethane; 24 H,Rt
    标题:Green Oxidations. Manganese(Ii) Sulfate Aided Oxidations Of Organic Compounds By Potassium Permanganate
    作者:Shaabani,Ahmad; Rahmati,Abbas; Sharifi,Masoumeh; Rad,Jafar Mogimi; Aghaaliakbari,Behnaz; Et Al
    参考文献:Monatshefte Fuer Chemie 日期:2007 卷标:138(7) 页码:649-651]

    92-83-1 = 90-47-1
    反应条件:1.1 Reagents: Alumina,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water
    标题:Selective Oxidation Of Arenes In Dry Media Under Focused Microwaves
    作者:Oussaid,Abdelouahad; Loupy,Andre
    参考文献:Journal Of Chemical Research 日期:1997 卷标:(9) 页码:342-343]

    492-21-7 = 90-47-1 [标题:Reaction Conditions
    标题:Photosensitized Chemiluminescent Desulfurization Of Arenethiones
    作者:Suzuki,Nobutaka; Sano,Kaniti; Tani,Noriyuki; Izawa,Yasuji
    参考文献:Heterocycles 日期:1981 卷标:16(7) 页码:1133-6]

    90-46-0 = 90-47-1
    反应条件:1.1 Solvents: Benzene
    标题:Oxidation Of Aromatic Alcohols With Manganese Dioxide
    作者:Turner,D. L.
    参考文献:Journal Of The American Chemical Society 日期:1954 卷标:76 页码:5175-6]

    2243-42-7 = 90-47-1
    反应条件:1.1 Reagents: Acetyl Chloride,Sulfuric Acid
    标题:A New Condensing Agent For The Preparation Of Benzo-γ-Pyrones,And The Mode Of Action Of Sulfoacetic Acid In Acetylations
    作者:Gottesmann,E.
    参考文献:Berichte Der Deutschen Chemischen Gesellschaft [abteilung] B: Abhandlungen 日期:1933 卷标:66 页码:1168-77]

    2243-42-7 = 90-47-1
    反应条件:1.1 Reagents: Trifluoroacetic Anhydride Solvents: Trifluoroacetic Acid; 12 H,Rt
    标题:Hydrogen Bond Donor Solvents Enabled Metal And Halogen-Free Friedel-Crafts Acylations With Virtually No Waste Stream
    作者:Liu,Guangchang; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(10) 页码:869-872]

    492-21-7 = 90-47-1
    反应条件:1.1 Reagents: Trifluoroacetic Anhydride Solvents: Acetonitrile
    标题:An Alternative Efficient Method For Transformation Of Thiocarbonyl To Carbonyl Group Using Trifluoroacetic Anhydride
    作者:Masuda,Ryoichi; Et Al
    参考文献:Tetrahedron Letters 日期:1991 卷标:32(9) 页码:1195-8]

    82-07-5 = 90-47-1
    反应条件:1.1 Reagents: Cesium Carbonate,4,7-Diphenyl-1,10-Phenanthroline,Oxygen Catalysts: Copper Oxide (Cuo),Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[3,5-Diflu... Solvents: Dichloromethane; Rt -> 40 °C; 40 H,40 °C
    标题:Decarboxylative Oxidation Of Carboxylic Acids Using Photocatalysis And Copper Catalysis
    作者:Zaman,Muhammad Kashif; Et Al
    参考文献:Synlett 日期:2023 卷标:34(17) 页码:2029-2033]

    82-07-5 = 90-47-1
    反应条件:1.1 Reagents: 2,4,6-Trimethylpyridine,Tetrabutylammonium Perchlorate,Water Catalysts: Tempo Solvents: Dichloromethane; 10 Min,Rt; 10 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Electrochemical Decarboxylative Oxygenation Of Carboxylic Acids
    作者:Meng,Xiangtai; Et Al
    参考文献:Acs Sustainable Chemistry & Engineering 日期:2022 卷标:10(15) 页码:5067-5071]

    = 90-47-1
    反应条件:1.1 Reagents: Trimethylamine Oxide Solvents: Acetonitrile
    标题:Oxo Transfer From Amine N-Oxides To Copper Salts: Resulting Copper(Iii) Mediated Oxidation Of Organic Ligands
    作者:Maumy,M.; Et Al
    参考文献:Studies In Surface Science And Catalysis 日期:1991 卷标:66 页码:665-73]

    329235-41-8 = 90-47-1
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Rt; 4 H,50 °C
    标题:Broadening The Catalyst And Reaction Scope Of Regio- And Chemoselective C-H Oxygenation: A Convenient And Scalable Approach To 2-Acylphenols By Intriguing Rh(Ii) And Ru(Ii) Catalysis
    作者:Shan,Gang; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2013 卷标:11(14) 页码:2318-2322
氧杂蒽置于叔丁基过氧化氢,Iron(Iii) Chloride,C42H40Cu2N8体系中,用 水,乙腈 作为反应溶剂,化学反应 16.0H,以90%的收率获得产物占吨酮
参考文献:富含地球的混合金属催化剂,用于碳氢氧合
标题:富含地球的混合金属催化剂,用于碳氢氧合
摘要:使用富含地球的铁和铜催化剂以及"绿色"氧化剂(例如过氧化氢)对脂肪族和芳香族烃的氧合对原子经济的化学加工越来越重要.有鉴于此,我们描述了吡咯席夫碱大环的双核cu Ii配合物与氯化铁(fecl 3)一起在室温和低负荷下用氢过氧化物氧化剂催化π活化苄基底物的氧化.氧化催化的新颖设计.质谱和扩展的x射线吸收精细结构分析表明,Cu Ii和fe Iii之间发生了协同作用,这很可能是由于fecl 3的相互作用或的fecl 4-与双核铜ii大环化合物.伏安法测量突出了对cu Ii和fe Iii的调制该加合物具有氧化还原电势,但电子顺磁共振波谱表明任何cu-Fe金属间相互作用都很弱.较高的酮/醇产物比率,较小的反应常数(hammett分析)和较小的h原子抽象动力学同位素效应都表明存在自由基反应.但是,与环己烷的反应性不足,9,10-二氢蒽的氧化,氢过氧化物mpph(自由基机理探针)的氧化以及二氮吹扫实验
DOI:10.1021/acs.Inorgchem.8B00420

海关参考信息

专利信息


专利号:US-6770436-B1
优先权日:1996-11-14
标题:Chemical amplification for the synthesis of patterned arrays
发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

专利号:US-4443310-A
优先权日:1981-03-12
标题:Photoinitiated synthesis of mercaptans
发明人:ARRETZ EMMANUEL; LANDOUSSY CLAUDE; MIRASSOU ALFRED; OLLIVIER JEAN
权利人:ELF AQUITAINE
摘要:Improvement in the photoinitiated synthesis of mercaptans, in which an ethylenic compound is treated with hydrogen sulphide, preferably under pressure, in the presence of ultraviolet radiation and a photoinitiator involves the use of a xanthenic compound, possibly substituted, as the initiator. Preferably, the xanthenic compounds is employed in conjunction with an organic compound of an element of Group V A of the Periodic Classification of the Elements.

专利号:US-2010137421-A1
优先权日:2006-11-08
标题 :Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
发明人:THEODORAKIS EMMANUEL; BATOVA AYSE
权利人:THEODORAKIS EMMANUEL; BATOVA AYSE
摘要:Provided herein are compounds that are inducers of apoptosis activators of caspases and pharmaceutically acceptable derivatives thereof. Also provided are methods of synthesis of the compounds and methods for treatment of diseases in which there is uncontrolled cell growth and spread of abnormal cells, such as cancers, by administering the compounds.

专利号:WO-2024260915-A1
优先权日:2023-06-19
标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof
发明人:GARMSHAUSEN YVES
权利人:XOLO GMBH
摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.

专利号:WO-2018011378-A1
优先权日:2016-07-13
标 题 :Method for the synthesis of a polyolefin by means of romp in the presence of a ruthenium-based catalyst
发明人:PINAUD JULIEN; CHEMTOB ABRAHAM; HEROGUEZ VALÉRIE; PLACET EMELINE; SAUVANIER DAVID; LACROIX-DESMAZES PATRICK
权利人:CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS); UNIV MONTPELLIER; UNIV BORDEAUX; BORDEAUX INP; UNIV HAUTE ALSACE; AXLR SATT DU LANGUEDOC ROUSSILLON; ENSCM
摘要:The present invention relates to a method for the synthesis of a polyolefin by means of a photoinitiated ROMP reaction involving a cyclic olefin in the presence of a ruthenium-based catalyst of formula (I), in which the catalyst is generated in situ under UV radiation from an inactive ruthenium complex of formula [RuCl 2 (L)] 2 and an imidazoli(ni)um salt of formula (III).

专利号:US-2005181421-A1
优先权日:2000-08-03
标题 :Methods of array synthesis
发明人:TRULSON MARK; MCGALL GLENN; FIDANZA JACQUELINE
权利人:AFFYMETRIX INC
摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers
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主要参考文献


1: Herder M, Lehn JM. The Photodynamic Covalent Bond: Sensitized Alkoxyamines as a Tool To Shift Reaction Networks Out-of-Equilibrium Using Light Energy. J Am Chem Soc. 2018 Jun 12. doi: 10.1021/jacs.8b03633. [Epub ahead of print] pii: E1396. doi: 10.3390/molecules23061396. doi: 10.1155/2018/3985082. eCollection 2018.
4: Patra N, Dehury N, Pal A, Behera A, Patra S. Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle. Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:439-445. doi: 10.1016/j.msec.2018.04.091. Epub 2018 May 1. doi: 10.1016/j.bcp.2018.05.002. [Epub ahead of print] pii: E1484. doi: 10.3390/ijms19051484.
10: Timsina B, Kindlmann P, Rokaya MB, Vrchotová N, Tříska J, Horník Š, Sýkora J. Xanthones Content in Swertia multicaulis D. Don from Nepal. Molecules. 2018 May 3;23(5). pii: E1067. doi: 10.3390/molecules23051067. doi: 10.1021/acs.orglett.8b00901. Epub 2018 May 8. doi: 10.1016/j.jtcme.2018.01.006. eCollection 2018 Apr. Review.

合成参考文献


参考文献:10.2174/092986710790712147
摘要:El-Seedi HR, El-Barbary MA, El-Ghorab DM, Bohlin L, Borg-Karlson AK, Göransson U, Verpoorte R. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17(9):854–901. doi: 10.2174/092986710790712147.
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