CAS: 73183-34-3; 4,4,4',4',5,5,5',5'-Octamethyl-2,2'-Bi(1,3,2-Dioxaborolane)

上下游产品

2,3-dimethyl-2,3-butane diol 2(NMe2)2(catecholate)1,2-B2(NMe2)2(catecholate) 4-tert-Butylcatechol boron trichloride1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 2-(2-tert-butoxyethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,4,5,5-tetramethyl-2-pentyl-1,3,2-dioxaborolane

频哪醇置于四(吡咯烷并)二硼烷体系中,用83%的收率获得产物联硼酸频那醇酯
参考文献:四(吡咯烷)二硼烷(4),[(c4H8N)2B]2,作为双(频哪醇)乙硼烷(4)的新改进替代合成路线-中间体的晶体结构
标题:四(吡咯烷)二硼烷(4),[(c4H8N)2B]2,作为双(频哪醇)乙硼烷(4)的新改进替代合成路线-中间体的晶体结构
摘要:化合物四(吡咯烷基)二硼烷(4)(3)是制备和合成双(频哪醇)二硼烷(4)的一种重要的新型替代前体.后者是乙硼烷衍生物中的主要中间体,用于许多加成和插入多个键的反应.确定了 3 及其前体三(吡咯烷基)硼烷 1 的晶体结构.此外,还检查了 3 与醇的溶剂分解反应和溶液行为.
DOI:10.1002/1099-0682(20021)2002:1<73::Aid-Ejic73>3.0.Co;2-1

专利信息

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-8357819-B2
优先权日:2007-05-11
标 题 :Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
发明人：BOITEAU JEAN-GUY
权利人:GALDERMA RES & DEV; BOITEAU JEAN-GUY
摘要:The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): n nand also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

专利号:US-2020079715-A1
优先权日:2018-09-06
标题 :2-position modification for synthesis of resorcinol scaffolding
发明人：DAVIS ROBERT; BLACK JACOB; SMELTZER THOMAS; COLVIN SEAN
权利人:CANOPY HOLDINGS LLC
摘要:A resorcinol with modifications at the 2-position is provided. The reactant resorcinol may have a variety of functional groups at each of the 1, 3, and 5 position such as a hydroxide, a lower alkyl group, a phenyl, a substituted phenyl, a lower alkenyl, or a lower alkynyl sp 2 carbon group (e.g., substituted phenyl, vinyl), sp (e.g., alkyne), hydrogen. The resorcinol is modified at the 2-position with a nucleophile or an electrophile. The resulting resorcinol may serve as a stable intermediate for the synthesis of cannabinoid or cannabinoid derivatives.

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.