CAS: 68609-96-1; Octyl/decyl Glycidyl Ether

专利信息

专利号:US-6858585-B1
优先权日:1996-06-25
标题 :Cyclic depsipeptides and drugs containing the same as the active ingredient
发明人：YANAI MAKOTO; SUZUKI MASASHI; OSHIDA NORIO; KAWAMURA KOJI; HIRAMOTO SHIGERU; YASUDA ORIE; KINOSHITA NOBUHIRO; SHINGAI AKIKO; TAKASU MASAKO
权利人:NISSHIN SEIFUN GROUP INC
摘要:Cyclic depsipeptides represented by the formula n n nwherein:n n R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.