CAS: 6829-40-9; Diethyl 2-Aminomalonate

该化合物是一种有机化合物,其特点是其狄氏功能组和一个氨基替代体,该化合物具有丙烷基酸脊椎,其中两个乙基酯组附于第一和第二碳原子,一个氨基组位于第二碳上,其一般色素不及色,可粉黄液体或固体,视其纯度和形态而定.氨基组的存在具有基本特性,使其得以参与各种化学反应,例如核糖核代和凝聚反应.该化合物经常用于有机合成,特别是用于制药和农用化学剂的制作.在标准条件下,其有机溶剂中的溶性以及中度稳定性使其在化学合成中成为多用途的中间体.在处理时,应参考安全数据,与所有化学物质一样,确保采取适当的预防措施.

结构式图片

相似化合物

13433-00-6 102831-44-7 26348-61-8

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合成工艺路线路线简述

  • 合成目标产物 2-Aminodiethylmalonate 主要起始原料 Diethyl Aminomalonate Hydrochloride
  • (文献来源)合成步骤主要原料 Diethyl Aminomalonate Hydrochloride
📜Sodium Diethylmalonate置于乙醇,镍体系中,40.0~50.0 °C,303.98 Kpa 条件下,反应生成 氨基丙二酸二乙酯
参考文献:Redemann; Dunn,Journal Of Biological Chemistry,1939,Vol. 130,P. 347
标题:Redemann; Dunn,Journal Of Biological Chemistry,1939,Vol. 130,P. 347

海关参考信息

专利信息


专利号:US-4503252-A
优先权日:1979-09-10
标题:Process for the preparation of serinol and of serinol derivatives, and products obtained therefrom
发明人:FELDER ERNST; BIANCHI SERGIO; BOLLINGER HEINRICH
权利人:EPROVA AG
摘要:A method for the synthesis of serinol and serinol derivatives substituted at the nitrogen atoms by reacting a lower 1,3-dialkoxy-isopropyl halide with ammonia or an amine to form a 1,3-dialkoxy-isopropylamine and then removing the ether groups by heating with a hydrogen halide acid. The method allows the production of serinol and serinol derivatives using inexpensive starting materials in a simple manner and obtaining a high purity product which is free of interfering isomers. Novel compounds obtained by the method which are useful as pharmaceutical intermediates, X-ray contrasting agents and cytostatic or psychopharmacological drugs are also disclosed.

专利号:CN-101367785-A
优先权日:2008-05-08
标题 :The Application of Synthesis of 2-Hydroxypropanedicarbonyl Compounds in the Synthesis of Flavonols

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

专利号:US-2004067531-A1
优先权日:1997-08-20
标 题:Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
发明人:TANG PENG CHO; SUN LI; TRAN NGOC MY; NGUYEN ANH THI; NEMATALLA ASAAD
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-2017008863-A1
优先权日:2008-02-22
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions

专利号:CN-106478485-A
优先权日:2016-09-08
标题 :A new method for the synthesis of indole glycine

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Hari, Y.; Aoyama, T.; Shioiri, T., Science of Synthesis Knowledge Updates, (2010) 4, 64.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 163.
摘要:Akiyama, T., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 201.
摘要:Inokuma, T.; Takemoto, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 437.
摘要:Liao, L.; Zhang, Y.; Yu, J.-S., Science of Synthesis: Knowledge Updates, (2024) 1, 215.
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