CAS: 591-95-7; 1,2-Pentadiene

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CAS号627-19-0 1-戊炔 | CAS号14035-68-8 3-chloropent-1-yne | CAS号4187-86-4 乙基乙炔基甲醇 | CAS号64-67-5 硫酸二乙酯 | CAS号463-49-0 丙二烯 | CAS号616-25-1 1-戊烯-3-醇 | CAS号4219-24-3 3-己烯酸 | CAS号20599-27-3 1-BROMO-2-PENTENE | CAS号689-97-4 乙烯基乙炔 | CAS号34557-54-5 methane | CAS号54509-73-8 ethene | CAS号74-99-7 丙炔 | CAS号627-19-0 1-戊炔 | CAS号627-21-4 2-戊炔 | CAS号31844-95-8 2-Bromo-1-pentene | CAS号54653-30-4 (E)-2-bromo-2-p... | CAS号54653-26-8 2,2-dibromopentane | CAS号3142-66-3 3-羟基-2-戊酮

📜1-戊烯-3-醇置于吡啶,氢氧化钾,乙醇,溴,三溴化磷,锌体系中,化学反应生成 1,2-戊二烯
参考文献:Membrane Currents In Cultured Human Intestinal Smooth Muscle Cells
标题:Membrane Currents In Cultured Human Intestinal Smooth Muscle Cells
摘要:1. Using Whole-Cell Patch-Clamp Recording Techniques,We Have Examined Voltage-Gated Ion Currents In A Cultured Human Intestinal Smooth Muscle Cell Line (Hism). Experiments Were Performed At Room Temperature On Cells After Passages 16 And 17.2. Two Major Components Of The Whole-Cell Current Were A Tetraethylammonium-Sensitive (Ic50 = 9 Mm),Iberiotoxin-Resistant,Delayed Rectifier K+ Current And A Na+ Current Inhibited By Tetrodotoxin (Ic50 Approximate To 100 Nm). No Measurable Inward Current Via Voltage-Gated Ca2+ Channels Could Be Detected In These Cells Even With 10 Mm Ca2+ Or Ba2+ In The External Solution. No Current Attributable To Calcium-Activated K+ Channels Was Found And No Cationic Current In Response To Muscarinic Receptor Activation Was Present.3. In Divalent Cation-Free External Solution Two Additional Currents Were Activated: An Inwardly Rectifying Hyperpolarization-Activated Current,I-Ha,And A Depolarization-Activated Current,I-Da.4. I-Ha And I-Da Could Be Carried By Several Monovalent Cations; The Sizes Of Currents In Descending Order Were: K+ > Cs+ > Na+ For I-Ha And Na+ > K+ Much Greater Than Cs+ For I-Da. I-Ha Was Activated And Deactivated Instantaneously And Showed No Inactivation Whereas I-Da Was Activated,Inactivated And Deactivated Within Tens Of Milliseconds. These Currents Were Inhibited By External Calcium With An Ic50 Of 0.3 Mum For I-Da And An Ic50 Of 20 Mum For I-Ha5. Cyclopiazonic Acid (Cpa) Induced An Outward,But Not An Inward Current. Sk&f 96365,A Blocker Of Store-Operated Ca2+ Channels,Suppressed I-Da With A. Half-Maximal Inhibitory Concentration Of 9 Mum But Was Ineffective In Inhibiting I-Ha At Concentrations Up To 100 Mum. Gd3+ And La3+ Strongly Suppressed I-Da At 1 And 10 Mum,Respectively And Were Less Effective In Blocking I-Ha (Complete Inhibition Required A Concentration Of 100 Mum For Both). Carbachol At 10-100 Mum Evoked About A S-Fold Increase In I-Ha Amplitude And Completely Abolished I-Da.6. We Conclude That I-Ha And I-Da,Are Ca2+-Blockable Cationic Currents With Different Ion Selectivity Profiles That Are Carried By Different Channels. I-Da Shows Novel Voltage-Dependent Properties For A Cationic Current.
DOI:10.1111/j.1469-7793.2000.00521.X

专利信息

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-7655769-B2
优先权日:2004-07-20
标题:Orthogonally protected disaccharide building blocks for synthesis of heparin
发明人：HUNG SHANG-CHENG; LEE JING-CHYI; LU XIN-AN
权利人:ACADEMIA SINICA
摘要:Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P 1 , P 2 , P 3 and P 4 are different, and of them P 1 is an ester-type protecting group, P 2 is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P 3 is a hydroxyl protecting group, and P 4 is a hydroxyl protecting group which allows chemoselective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin saccharide of desired size.

专利号:US-2007049757-A1
优先权日:2005-08-26
标题:Methods for the synthesis of substituted amino uracils
发明人：RIEGER JAYSON M; THOMPSON ROBERT
权利人:RIEGER JAYSON M; THOMPSON ROBERT
摘要:The invention provides novel methods of preparing substituted amino uracil compounds that can be employed as useful intermediates in the synthesis of various xanthines. Highly regioselective unsymmetrical amino uracils can be obtained using these methods which is a particular advantage over other existing methods.

专利号:US-7632975-B2
优先权日:2004-12-22
标 题:Process for the synthesis of arylfluorenes and analogs thereof
发明人：HEIDENHAIN SOPHIE
权利人:CDT OXFORD LTD
摘要:A process is provided for the synthesis of a compound of formula (I): n nwherein:n M=0 or 1; N and p are 0 or 1 to 4; X is a single bond, O, S or NH; And R 1 -R 4 are as defined in claim 1.