CAS: 57294-38-9; Boc-Gaba-Oh

该化合物是一种氨基酸衍生物,是一种氨基酸衍生物,其特点是与氨基丁基碳酸结构的伽马位置相连,是一种乙基-丁氧碳基(Boc)保护组,该组通常为白色至非白色固体,在二氯甲烷和二甲基硫氧化物等有机溶剂中可溶解,但在水中可溶解. Boc组是氨基生物群的保护性动物,通过防止不必要的侧面反应,促进其在浸泡合成和其他有机反应中的使用.BOC-GABA由于在化学转化过程中有能力加强氨基酸的稳定性和溶性,因此经常用于合成药物和生物活性化合物.此外,可以在温和的酸性条件下进行保护,允许自由氨基氨基组再生,以便进一步发挥作用.其独特的结构和特性使它成为医药化学和浸酸合成中有价值的中间体.

结构式图片

相似化合物

5105-78-2 56-12-2 94994-39-5

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合成工艺路线路线简述

    4-氨基丁酸置于三乙胺体系中,用 甲醇 作为反应溶剂,化学反应生成 N-Boc-Gamma-氨基丁酸
    参考文献:Mcr Dendrimers
    标题:Mcr Dendrimers
    摘要:这项发明涉及一种通过多次迭代多组分反应(mcr),特别是ugi或passerini多组分反应,来制备肽样,肽和嵌合肽-肽样树状聚合物的方法,以及通过这种方式生产的化合物的用途.

    海关参考信息

    专利信息


    专利号:US-6683189-B1
    优先权日:1996-02-26
    标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
    发明人:DERVAN PETER B; BAIRD ELDON
    权利人:CALIFORNIA INST OF TECHN
    摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

    专利号:US-2022098170-A1
    优先权日:2019-01-16
    标 题 :Process for the synthesis of gepirone
    发明人:COLOMBANO GIAMPIERO; BARBERO MAURO; GIOVENZANA GIOVANNI BATTISTA; ROLETTO JACOPO; PAISSONI PAOLO
    权利人:PROCOS SPA
    摘要:Disclosed is a process for the synthesis of gepirone of formula (I) from 8-(pyrimidin-2-yl)-5,8-diazaspiro[4,5]decan-5-ium bromide. The process according to the invention is economically efficient and easily industrially scalable.

    专利号:US-11738092-B2
    优先权日:2019-12-04
    标题:Methods and compositions for synthesis of therapeutic nanoparticles
    发明人:WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
    权利人:DANTARI INC
    摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-5783577-A
    优先权日:1995-09-15
    标题 :Synthesis of quinazolinone libraries and derivatives thereof
    发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

    专利号:US-2023295613-A1
    优先权日:2020-02-14
    标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
    发明人:JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
    权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
    摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
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    主要参考文献

    [参考文献]: Potjewyd F, Et Al. Degradation Of Polycomb Repressive Complex 2 With An Eed-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.E15.

    合成参考文献


    参考文献:10.1055/s-0037-1611018
    摘要:Vázquez A, Morales-Chamorro M. A Facile Synthesis of N-Boc-azocan-5-one. Synthesis. 2018 Oct 10;51(04):842–7. doi: 10.1055/s-0037-1611018.
    参考文献:10.1055/s-0030-1257764
    摘要:Synthesis of (-)-Actinophyllic Acid. Synfacts. 2010 Jul 22;2010(08):0862. doi: 10.1055/s-0030-1257764.
    参考文献:10.1055/s-0041-1738592
    摘要:A β-Lactone for Covalent Inhibition of KRAS G12S. Synfacts. 2022 Sep 20;18(10):1141. doi: 10.1055/s-0041-1738592.
    参考文献:10.1007/s11094-023-02834-z
    摘要:Guseva MK, Budanova UA, Sebyakin YL. Synthesis and Evaluation of the Antimicrobial Activity of Cationic Amphiphiles Based on Bivalent Diethylenetriamine Derivatives. Pharm Chem J. 2023 Mar;56(12):1607–12. doi: 10.1007/s11094-023-02834-z.
    参考文献:10.1007/s11426-024-2210-2
    摘要:Zhang Y, Zhou P, Ma X, Yang X, Fang X, Wang Y, Shu C. Bisulfite-mediated base-free decarboxylative carbonylsulfination of alkenes: access to β-keto sultines. Sci. China Chem. 2024 Sep 24;68(2):622–30. doi: 10.1007/s11426-024-2210-2.
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