专利号:US-5012000-A 优先权日:1989-10-30 标 题 :Total synthesis of chiral 2-amino-1,3-diols 发明人:ILLIG CARL R; WEIS ALEXANDER L 权利人:EASTMAN KODAK CO 摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.
专利号:US-8558012-B2 优先权日:2009-03-02 标 题:2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound using the same 发明人:SHIBATA NORIO 权利人:SHIBATA NORIO; NAGOYA INST TECHNOLOGY; TOSOH P TECH INC 摘要:A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a straight-chain or branched alkyloxy group having 1 to 4 carbon atoms, a halogen atom, a nitro group, or a cyano group), the production method thereof, and various monofluoromethyl group-containing compounds are manufactured using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethylating agent.
专利号:US-4609744-A 优先权日:1983-04-21 标题 :4-oxo-benzopyran carboxylic acids 发明人:YOUNG ROBERT N; ROKACH JOSHUA; WILLIAMS HAYDN R; KAKUSHIMA MASATOSHI; GUINDON YVAN 权利人:MERCK FROSST CANADA INC 摘要:Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
专利号:CN-120004747-A 优先权日:2025-02-17 标题 :Synthesis method of fingolimod hydrochloride