CAS: 455-18-5; 4-(Trifluoromethyl)Benzonitrile

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CAS号66046-34-2 N-[[4-(trifluor... | CAS号402-43-7 对溴三氟甲苯 | CAS号3300-51-4 对三氟甲基苄胺 | CAS号1891-90-3 4-(三氟甲基)苯甲酰胺 | CAS号151-50-8 氰化钾 | CAS号75-86-5 丙酮氰醇 | CAS号129946-88-9 S-(三氟甲基)二苯并噻吩三氟甲基磺酸盐 | CAS号126747-14-6 4-氰基苯硼酸 | CAS号557-21-1 氰化锌 | CAS号34898-30-1 2-[4-(三氟甲基)苯基]-1H-咪唑 | CAS号3300-51-4 对三氟甲基苄胺 | CAS号38980-96-0 4-三氟甲基苯脒盐酸盐 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号143703-84-8 2-pyridin-4-yl-... | CAS号184778-31-2 N'-Hydroxy-4-(t... | CAS号2251-79-8 5-[4-(三氟甲基)苯基]-1H-四唑 | CAS号15996-84-6 1-(4-(三氟甲基)苯基)乙胺 | CAS号72505-21-6 4-三氟甲基硫代苯甲酰胺 | CAS号71682-94-5 4-三氟甲基苯甲酰基乙腈

4-Trifluoromethylbenzyl Azide置于al2O3-Supported Ruthenium Hydroxide,Air体系中,用 甲苯 作为反应溶剂,80.0 °C,101.33 Kpa 条件下,反应 12.0H,以82%的收率获得产物对三氟甲基苯腈
参考文献:氢氧化钌催化剂将伯叠氮有氧氧化转化为腈
标题:氢氧化钌催化剂将伯叠氮有氧氧化转化为腈
摘要:在易于制备的负载型氢氧化钌催化剂存在下,Ru(oh)x / Al 2 O 3,各种结构多样的伯叠氮化物(包括苄基,烯丙基和脂肪族的)可以以中等至高收率转化成相应的腈(13个实例,收率65-94%).与小规模(0.5 Mmol)转化相比,苄基叠氮化物的克级(1 G)转化有效地进行,得到苄腈(0.7 G,90%收率),性能没有任何下降.催化确实是非均相的,回收的催化剂可以重复用于苄基叠氮化物的转化,而不会明显丧失其高性能.当前的叠氮化物向腈的转化可能通过酰亚胺形成的顺序反应进行,然后进行脱氢(β-消除)以产生相应的腈.ru(oh)x /铝通过将伯叠氮化物(苄基和脂肪族的)转化为腈,然后依次水合形成的腈,可以进一步使用2 O 3催化剂在水中合成酰胺.此外,可以使用ru(oh)x / Al 2 O 3从烷基卤化物和tban 3(tba =四正丁基铵)直接进行一锅合成,从而以中等至高收率得到相应的腈(10个例子,
DOI:10.1021/jo2004956

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-2009264680-A1
优先权日:2004-07-07
标题:Process for the synthesis and purification of (4-methoxybutyl) (4-trifluoromethylphenyl) methanone
发明人：CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
权利人:CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
摘要:A process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the organomagnesium specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-6380436-B1
优先权日:1998-05-12
标 题 :Process for the synthesis of alkoxyalkyl (trifluormethylphenyl) methanones
发明人：THENNATI RAJAMANNAR; DEO KESHAV; MIDHA AJAY SOHANLAL; CHANDRA TILAK; PATEL VIJAY MULJIHHAI
权利人:SUN PHARMACEUTICAL IND LTD
摘要:A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.