CAS: 4521-61-3; 3,4,5-Trimethoxybenzoyl Chloride

上下游产品

CAS号118-41-2 3,4,5-三甲氧基苯甲酸 | CAS号1916-07-0 3,4,5-三甲氧基苯甲酸甲酯 | CAS号884-35-5 丁香酸甲酯 | CAS号10026-13-8 五氯化磷 | CAS号75-15-0 二硫化碳 | CAS号71-43-2 苯 | CAS号104575-36-2 2-(2-Methyl-5-n... | CAS号1041-10-7 1-Propanone,3-(... | CAS号112290-20-7 2-(3,4,5-trimet... | CAS号964-65-8 piperazin-1-yl-... | CAS号1062-48-2 [4-(3,4,5-trime... | CAS号3291-03-0 3,4,5-三甲氧基苯甲酰肼 | CAS号4336-70-3 (氰甲基)三苯基氯化膦 | CAS号86213-25-4 3-oxo-3-(3,4,5-... | CAS号22699-97-4 Methanone,(3,4-... | CAS号1866-76-8 (fluoren-9-ylid...

丁香酸甲酯置于sodium Hydroxide,氯化亚砜,四丁基硫酸氢铵,Potassium Carbonate体系中,用 甲苯 作为反应溶剂,化学反应 8.25H,反应生成 3,4,5-三甲氧基苯甲酰氯
参考文献:开发一系列新的三烷氧基芳基衍生物作为血小板活化因子的特异性和竞争性拮抗剂.
标题:开发一系列新的三烷氧基芳基衍生物作为血小板活化因子的特异性和竞争性拮抗剂.
摘要:描述了一系列新的三烷氧基芳基衍生物作为血小板活化因子(paf)的特异性和竞争性抑制剂的合成和结构活性关系(sar)分析.paf与已知拮抗剂银杏内酯b和l-652731的分子模型比较导致选择n-[2-[(3,4,5-三甲氧基苯甲酰基)氧基]乙基]-N,N,N-三甲基碘化铵(1),从化合物的wellcome登记册到合成先导化合物n-[2-[[4-(己氧基)-3,5-二甲氧基苯甲酰基]氧基]乙基]-N,N,N-三甲基碘化铵(3,Pkb 5.43).进一步的sar考虑使该设计针对一种新颖,特异且新颖的2-(己氧基)-1,3-二甲氧基-5-[4-(4-甲基噻唑-5-基)丁基]苯(38)(pkb 7.14).兔洗血小板中paf受体的竞争性抑制剂.
DOI:10.1021/jm00012A012

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-2005130221-A1
优先权日:2001-02-01
标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents
发明人：FLYNN BERNARD L; HAMEL ERNEST
权利人:US GOV HEALTH & HUMAN SERV
摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.

专利号:US-7468438-B2
优先权日:2004-03-25
标题:Process for the semisynthesis of deserpidine
发明人：FONTANA GABRIELE; BOMBARDELLI EZIO; SAMORI CRISTIAN; BALDELLI ELEONORA; GUERRINI ANDREA; BATTAGLIA ARTURO; DANIELI BRUNO
权利人:INDENA SPA
摘要:The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-2022402908-A1
优先权日:2019-07-08
标题 :Cxcr6 inhibitors and methods of use
发明人：PEDDIBHOTLA SATYAMAHESHWAR; HERSHBERGER PAUL M; KIRBY RICHARD JASON; MALANY SIOBHAN; SMITH LAYTON H; MALONEY PATRICK R; SESSIONS HAMPTON; DIVLIANSKA DANIELA; PINKERTON ANTHONY B
权利人:SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST
摘要:Provided herein are small molecule inhibitors of CXCR6 receptor, compositions comprising the compounds, and methods of using the compounds and compositions. The compounds are 9-azbicyclo[3.3.1]nonane or 9-diazbicyclo[3.3.1]nonane derivatives, whose synthesis is also described. Also provided are method of treating a disease or condition (such as, cancer) mediated by CXCR6/CXCL16 signaling pathway in a mammal.

专利号:US-8536205-B2
优先权日:2005-05-25
标 题 :Photochromic and electrochromic compounds and synthesis and use thereof
发明人：BRANDA NEIL R; WUESTENBERG BETTINA; LEMIEUX VINCENT; ADAMS MICHAEL; GAUTHIER SIMON
权利人:BRANDA NEIL R; WUESTENBERG BETTINA; LEMIEUX VINCENT; ADAMS MICHAEL; GAUTHIER SIMON; SWITCH MATERIALS INC
摘要:Photochromic and electrochromic hexadiene compounds that are reversibly convertible between ring-open and ring-closed isomeric forms. The conversion between the different isomeric forms may be induced by light or electricity. The compounds may include a charge transfer moiety including electron donor and acceptor groups. The electron donor and acceptor are linearly conjugated in the ring-open form to enable electron transfer but are electrically insulated in the ring-closed form. Photoresponsive compounds may be synthesized by any of several methods disclosed, e.g., by reacting diene precursors with dienophiles in a condensation reaction. The compounds may be utilized in reactivity-gated photochromic or electrochromic applications. Compounds may be used in a method to selectively release a releasable agent, such as a small molecule.