CAS: 38395-02-7; (3S,8S,9R,10R,12R,13S,14R,17S)-17-Acetyl-3,8,14,17-Tetrahydroxy-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-12-Yl (E)-3,4-Dimethylpent-2-Enoate
该化合物是一种化学化合物,属于被称为alkaloids的天然产品类别,主要来自某些植物物种,特别是同类生物*Corydalis*.Caudatin的特点是复杂的分子结构,包括多种环和有助于其生物活动的功能组.该化合物由于其潜在的治疗特性,包括抗炎和止痛作用,引起了对药学的兴趣.此外,研究表明,Caudatin可能表现出抗癌特性,使其成为医学化学领域研究的课题,其溶性,稳定性和再活性可因诸如PH和所使用的溶剂等条件而变化.与许多自然产品一样,提取和净化过程对于以适合进一步研究或应用的形式获得土豆锡至关重要.
- 英文名称(3S,8S,9R,10R,12R,13S,14R,17S)-17-Acetyl-3,8,14,17-Tetrahydroxy-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-12-Yl (E)-3,4-Dimethylpent-2-Enoate
- 中文名称告达亭甙元
- IUPAC名称(3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl (E)-3,4-dimethylpent-2-enoate
- 其它别名Cauldatinpregn-5-En-20-One,12-[[(2E)-3,4-Dimethyl-1-Oxo-2-Pentenyl]Oxy]-3,8,14,17-Tetrahydroxy-,(3β,12β,14β,17α)-
- CAS编号38395-02-7
- MFCD编号:MFCD32000895
- 分子式:C28H42O7分子量:490.64
- 产品CID: 1396014
- 产品分类天然产物 → 甾体化合物
物理性质
- 沸点617.9±55.0 °C at 760 mmHg
- 闪点197.5±25.0 °C
- 密度1.3±0.1 g/cm3
- pKa:11.93±0.70(预测)
- PSA:124.29
- LogP:4.37
- 折射率1.584
- 蒸汽压0.0±4.1 mmHg at 25°C
- 溶解性DMF:30.0(Max Conc. mg/mL);61.15(Max Conc. Mm) DMSO:30.0(Max Conc. mg/mL);61.15(Max Conc. Mm) Ethanol:30.0(Max Conc. mg/mL);61.15(Max Conc. Mm) Ethanol:Pbs (Ph 7.2) (1:7):0.12(Max Conc. mg/mL);0.24(Max Conc. Mm)
- 外观形态白色至类白色固体
- 储存条件4°C, 避光
- 产品应用该化合物用作内容确定,化合物识别和药理研究;展示抗肿瘤,抗癫痫,免疫细胞,抗氧化剂和抗病毒活动.
MSDS等安全信息
- 警示词warning
- 危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
合成工艺路线路线简述
海关参考信息
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2905122000-异丙醇
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bailly C. Anticancer properties of caudatin and related C-21 steroidal glycosides from Cynanchum plants. Steroids. 2021 Aug;172:108855. doi: 10.1016/j.steroids.2021.108855. Epub 2021 May 1. 45(12):2907-2915. Chinese. doi: 10.19540/j.cnki.cjcmm.20200228.201. 22(2):697-706. doi: 10.3892/mmr.2020.11135. Epub 2020 May 7.
4: Zhen X, Choi HS, Kim JH, Kim SL, Liu R, Ko YC, Yun BS, Lee DS. Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling. Biomolecules. 2020 Jun 18;10(6):925. doi: 10.3390/biom10060925.
5: Chen WH, Zhang ZZ, Ban YF, Rahman K, Ye BZ, Sun XL, Tan HY, Zheng XH, Liu HY, Xu LC, Yan B, Han T. Cynanchum bungei Decne and its two related species for "Baishouwu": A review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2019 Oct 28;243:112110. doi: 10.1016/j.jep.2019.112110. Epub 2019 Jul 24.
合成参考文献
参考文献:10.1016/j.phymed.2008.02.021
摘要:Peng YR, Li YB, Liu XD, Zhang JF, Duan JA. Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight. Phytomedicine. 2008 Nov;15(11):1016–20. doi: 10.1016/j.phymed.2008.02.021.
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