CAS: 355-80-6; 2,2,3,3,4,4,5,5-Octafluoro-1-Pentanol

相似化合物

376-18-1 2264-00-8 2795-50-8

上下游产品

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2,2,3,3,4,4,5,5-八氟戊酸乙酯置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应生成2,2,3,3,4,4,5,5-八氟-1-戊醇
参考文献:在4-氨基喹啉的侧链中引入3-(2,2,2-三氟乙基)-γ-羟基-γ-内酰胺基.合成与抗疟活动
标题:在4-氨基喹啉的侧链中引入3-(2,2,2-三氟乙基)-γ-羟基-γ-内酰胺基.合成与抗疟活动
摘要:在本文中,我们报告了衍生自4-氨基喹啉的两种系列氟烷基化γ-内酰胺类化合物的合成及抗疟疾特性,它们是用于治疗疟疾的有效化学治疗剂.通过分几步获得的这些分子导致鉴定出非常有效的结构,具有体外活性,可对19-50 Nm范围内的可变敏感性(3D7和w2)恶性疟原虫克隆产生抗性,抗性指数在1.0-2.5范围内.此外,所选择的分子(50,51,58,60,63,70,72,74,78,81,84,和87)代表这两个系列的化合物,当针对浓度高达100μm的人脐静脉内皮细胞进行体外测试时,在体外未显示细胞毒性.最有前途的化合物(82和84)对氯喹敏感菌株3D7的ic 50值接近26和19 Nm,对耐多药菌株w2的ic 50值接近49和42 Nm.此外,发现两种模型化合物(50和70)在ph 7.4和5.2下可在48小时内保持稳定.总体而言,我们的初步数据表明此类结构包含有希望进一步研究的候选对象.
Doi:10.1021/jm301076Q

专利信息

专利号:US-2013197280-A1
优先权日:2009-12-29
标 题:Synthesis of fluorinated olefins from fluorinated alcohols
发明人：STEPANOV ANDREI ALEKSANDROVICH; CHERSTKOV VICTOR FILIPPOVICH; NAPPA MARIO JOSEPH
权利人:STEPANOV ANDREI ALEKSANDROVICH; CHERSTKOV VICTOR FILIPPOVICH; NAPPA MARIO JOSEPH; DU PONT
摘要:Disclosed is a process for producing a hydrofluoroalkene, R f CFâ•?CH 2 comprising contacting a hydrofluoroalkanol of structure R f CF 2 CH 2 OH, with a lewis acid to produce a mixture, diluting said mixture with a solvent to produce a solvent mixture, contacting the solvent mixture with a reactive metal, heating the solvent mixture and reactive metal for a sufficient amount of time to produce a hydrofluoroalkene, and condensing and collecting the volatile products comprising the hydrofluoroalkene, wherein R f is F, or a fluorine-substituted alkyl group.

专利号:US-2004249147-A1
优先权日:2001-09-25
标题:Synthesis of key azole-antifungal intermediates
发明人：SATTIGERI JITENDRA; ARORA JASBIR SINGH; MALHOTRA SANJAY; VERMA ASHWANI KUMAR; SALMAN MOHAMMAD
摘要:Methods for producing azole compounds useful as intermediates for antifungal compounds and compositions including reaction of epoxy alcohols with reactants having active hydrogen attached to nitrogen, oxygen or sulfur in the presence of redox coupling agents. In some embodiments, a procedure known as a Mitsunobu reaction is utilized for the transformations.

专利号:JP-2011528711-A
优先权日:2008-07-21
标题 :Method for aqueous synthesis of fluorinated sulfonate esters

专利号:CN-117945859-A
优先权日:2024-03-26
标题 :Synthesis of o-fluorophenol

专利号:EP-1432704-A1
优先权日:2001-09-25
标题:Synthesis of key azole-antifungal intermediates

专利号:WO-03027103-A1
优先权日:2001-09-25
标 题 :Synthesis of key azole-antifungal intermediates