CAS: 33070-32-5; 5-Bromo-2,2-Difluorobenzodioxole

上下游产品

2,2-二氟-1,3-苯并二恶茂 2,2-Difluoro-1,3-Benzodioxole 1583-59-1

4-溴邻苯二酚置于4-二甲氨基吡啶,Silver Fluoride体系中,用 二氯甲烷 作为反应溶剂,化学反应 6.0H,反应生成 5-溴-2,2-二氟-1,3-苯并二噁唑
参考文献:用氟化银(i)对硫代苯并二恶唑进行氟硫磺化.
标题:用氟化银(i)对硫代苯并二恶唑进行氟硫磺化.
摘要:二氟苯并二恶唑是在药物和农用化学品中都发现的重要官能团.hf和强氧化剂的典型氟化条件挑战了该官能团的后期引入.在这里,我们证明了可以从儿茶酚中分两步制备一系列二氟苯并二恶唑,方法是将其转化为硫代苯并二恶唑,然后用氟化银(i)进行脱硫氟化.这些温和的反应条件可与多种官能团兼容,并能够使用一系列官能化的二氟苯并二恶唑.
DOI:10.1021/acs.Joc.0C01729

专利信息

专利号:US-12098126-B2
优先权日:2021-08-23
标题:Methods of iron catalyzed C-H bond amination
发明人：CHE CHI-MING; YOU TINGJIE
权利人:VERSITECH LTD; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.

专利号:WO-2024185814-A1
优先权日:2023-03-06
标题:Method for producing aryl compound containing tritylsulfanyl group
发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
权利人:AGC INC; UNIV TOKYO
摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

专利号:US-6878665-B2
优先权日:2001-09-28
标题:Diphosphines, their complexes with transisition metals and their use in asymmetric synthesis
发明人：DUPRAT DE PAULE SEBASTIEN; CHAMPION NICOLAS; VIDAL VIRGINIE; GENET JEAN-PIERRE; DELLIS PHILIPPE
权利人:SYNKEM
摘要:The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): n n nin which:n R 1 and R 2 are a (C 5 -C 7 )cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH 2 —CH 2 ) or CF 2 . nn The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

专利号:EP-3835297-B1
优先权日:2010-03-25
标题:Synthesis and intermediates of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide
发明人：KESHAVARZ-SHOKRI ALI; ZHANG BEILI; ALCACIO TIM EDWARD; LEE ELAINE CHUNGMIN; ZHANG YUEGANG; KRAWIEC MARIUSZ
权利人:VERTEX PHARMA

专利号:CN-117700459-B
优先权日:2023-12-25
标题 :Synthesis and application of a type of benzo five-membered C-P ring skeleton monophosphine ligand

专利号:CN-117700459-A
优先权日:2023-12-25
标 题:Synthesis method and application of a type of benzo five-membered C-P ring skeleton monophosphine ligand