专利号:US-2021253509-A1 优先权日:2018-06-28 标 题 :Synthesis of (+)-cannabinoids and their therapeutic effects
专利号:EP-1300403-A1 优先权日:2001-10-02 标 题 :Process for the manufacture of hypoxyxylerone derivatives 发明人:GIMBERT YVES; CHEVENIER EMMANUEL; GREEN ANDREW E; MASSARDIER CHRISTINE; PIETTRE ARNAUD 权利人:AVENTIS PHARMA SA 摘要:The present invention relates to the total synthesis ofnhypoxyxylerone derivatives (formula I) and their biologicalnactivities. n R1-R5 are as described in the description.
专利号:US-9359298-B2 优先权日:2011-12-23 标题:Cajanine structure analogous compound, preparation method and use 发明人:LI ZHUORONG; JI XINGYUE; Xue situ; ZHENG GUANGHUI; LI YUHUAN; TAO PEIZHEN; JIANG JIANDONG 权利人:INST MED BIOTECHNOLOGY CAMS 摘要:Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
专利号:CN-101817745-A 优先权日:2009-12-29 标 题:A kind of chemical synthesis method of 3,5-dichloro-4-hydroxyl-2-methoxy-6-methyl-benzoic acid
参考标题:Enantioselective Synthesis Of The 3C-Protease Inhibitor (-)-Thysanone By A Staunton-Weinreb Annulation Strategy 作者:Margaret Brimble,Jonathan Sperry,Tsz Yuen |发布日期:2009.8 摘要:The Total Synthesis Of (-)-Thysanone Is Described. The Key Step Involves The Addition Of An O-Toluate Anion To A Lactone To Create The Naphthopyran Framework (Staunton-Weinreb Annulation). This Synthesis Further Confirms The Absolute Stereochemistry Of The Natural Product To Be 1R,3S. Thysanone - Staunton-Weinreb Annulation - Total Synthesis - Natural Products - Polycycles
合成参考文献
参考文献:10.1038/ncb3255 摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96. 摘要:Marsini, M. A.; Pettus, T. R. R., Science of Synthesis, (2007) 31, 457.