CAS: 24066-82-8; Ethyl 2-Isothiocyanatoacetate

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2949-22-6 623-33-6 1835759-69-7

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CAS号2999-46-4 异氰基乙酸乙酯 | CAS号463-71-8 硫光气 | CAS号623-33-6 甘氨酸乙酯盐酸盐 | CAS号75-15-0 二硫化碳 | CAS号459-73-4 2-胺基乙酸乙酯 | CAS号105290-10-6 ethyl [N-(ethyl... | CAS号7364-53-6 N-(Trimethylsil... | CAS号60-29-7 乙醚 | CAS号541-41-3 氯甲酸乙酯 | CAS号503-87-7 2-硫代乙内酰脲 | CAS号21198-09-4 ethyl 2-(aminot... | CAS号23176-01-4 ethyl 2-(4-oxo-... | CAS号2010-15-3 3-苯基-2-硫代乙内酰脲 | CAS号1309456-13-0 3-Thiazolidinea... | CAS号104892-41-3 ethyl 2-(phenyl... | CAS号26029-01-6 4-ETHYL-5-PYRID... | CAS号27484-49-7 diethyl [1,3]th... | CAS号61416-54-4 ethyl 2-isothio...

异氰基乙酸乙酯置于mo(O)(S2Cnet2)2 硫化丙烯体系中,用 二氯甲烷 用作溶剂,化学反应 72.0H,以87%的收率获得异硫氰基乙酸乙酯
参考文献:Direct Synthesis Of Isothiocyanates From Isonitriles By Molybdenum-Catalyzed Sulfur Transfer With Elemental Sulfur
标题:Direct Synthesis Of Isothiocyanates From Isonitriles By Molybdenum-Catalyzed Sulfur Transfer With Elemental Sulfur
摘要:The Direct Molybdenum-Catalyzed Sulfuration Of A Variety Of Isonitriles With Elemental Sulfur Or Propene Sulfide As Sulfur Donors Affords The Corresponding Isothiocyanates In Good Yields And Under Mild Reaction Conditions. A Catalytic Cycle Is Suggested,In Which The Molybdenum Oxo Disulfur Complex Operates As The Active Sulfur-Transferring Species. A Novel Adduct Between The Isonitrile And The Molybdenum Complex Has Been Characterized By X-Ray Analysis And Its Association Constant Determined By Uv-Vis Spectroscopy,But This Adduct Appears Not To Be Involved In The Sulfur-Transfer Process.
Doi:10.1021/jo026042I

专利信息

专利号:US-2011166152-A1
优先权日:2008-10-02
标题 :Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.

专利号:US-2010197692-A1
优先权日:2007-07-20
标 题 :Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：RAMTOHUL YEEMAN K; LI CHUN SING; LECLERC JEAN-PHILIPPE
权利人:MERCK FROSST CANADA LTD
摘要:Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.

专利号:WO-9213530-A1
优先权日:1991-02-11
标题 :Transglutaminase enzyme inhibitors
发明人：CHEN GEORGE T
权利人:MEDICIS CORP
摘要:The present invention relates to a composition and method for regulating protein crosslinking by transglutaminase enzymes in an animal or human. More particularly, the present invention relates to a series of novel transglutaminase enzyme inhibitors having the general formula: R-C=O-(CH2)n-NCS, wherein R is selected from the group consisting of O-CH3, O-CH2-CH3, O-Ø, O-Bz, and NH2 and n is an integer between 1 and 4, to their synthesis, and to their use in the treatment of crosslinking and amine incorporation disorders.