CAS: 20989-17-7; (S)-2-Amino-2-Phenylethanol

上下游产品

CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号6591-61-3 methyl (2S)-ami... | CAS号15028-39-4 (S)-(+)-2-苯基甘氨酸甲酯 | CAS号118958-06-8 N-[(2R,4E)-2-Me... | CAS号130406-31-4 Benzyl [(1S)-2-... | CAS号20989-17-7 L-苯甘氨醇 | CAS号20780-53-4 (R)-环氧苯乙烷 | CAS号582-24-1 2-羟基苯乙酮 | CAS号100-52-7 苯甲醛 | CAS号103548-06-7 2-methoxymethox... | CAS号1052209-96-7 (S)-5-苯基吗啉-3-酮 | CAS号143140-06-1 (3S-顺)-(+)-2,3-... | CAS号950194-37-3 (-)-苯并四咪唑 | CAS号914299-79-9 (S)-3-苯基吗啉 | CAS号174500-20-0 2,6-双[|4S|-4-苯基... | CAS号1908-90-3 4-苯基噻唑啉-2-硫酮 | CAS号180999-20-6 methyl N-[(1S)-... | CAS号194156-28-0 (2S)-1-(4-nitro... | CAS号185250-39-9 2-methylidene-1... | CAS号582-24-1 2-羟基苯乙酮

2-羟基苯乙酮置于葡萄糖,Glucose Dehydrogenase From Bacillus Subtilis,磷酸吡哆醛,R(+)-Alpha-甲基苄胺,Sodium Pyruvate,Amine Transaminase From Capronia Epimyces,Lactate Dehydrogenase From Bacillus Subtilis,聚甘氨酸,还原型辅酶ⅰ,Sodium Hydroxide体系中,用 二甲基亚砜 用作溶剂,以99%的收率获得
参考文献:涉及关键胺转氨酶的内消旋环氧化物生物催化不对称开环生成对映体纯环反式-β-氨基醇
标题:涉及关键胺转氨酶的内消旋环氧化物生物催化不对称开环生成对映体纯环反式-β-氨基醇
摘要:手性环状 β-氨基醇是合成众多药物和生物活性分子的重要组成部分.环状内消旋环氧化物的不对称开环是一种简单且有吸引力的合成方法.然而,为这一过程开发一种环保且具有成本效益的方法仍然难以实现.本文描述了通过环状内消旋环氧化物的完全生物催化不对称开环合成对映体纯的环状β-氨基醇.发现了一种来自capronia Epimyces的新型胺转氨酶 (Cepta),它对小分子环 α-羟基酮具有相当的活性和优异的对映选择性,并被证明对多种底物有效.还进行了同源建模,分子对接和分子动力学模拟,以阐明 Cepta 对小环 α-羟基酮的高效催化机制.通过使用重组大肠杆菌(Speh-Anddh-Bsldh) 和大肠杆菌(Cepta) 静息细胞的组合,成功实现了环状内消旋环氧化物 ( 4'j-k )的不对称开环,从而产生了环状内消旋环氧化物. (1 R,2 R )-反式-β-氨基醇( 1'j-k ) 转化率高达 81
Doi:10.1039/d4Gc00827H

专利信息

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-9988364-B1
优先权日:2017-03-21
标题 :Process for synthesis of Eliglustat and intermediate compounds thereof
发明人：LIU YU; YU GUANNENG; ZHENG ZHIGUO
权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.

专利号:US-7692019-B2
优先权日:2000-12-04
标 题:Methods for the stereoselective synthesis of substituted piperidines
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.

专利号:US-2012203004-A1
优先权日:2009-08-13
标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
发明人：ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.