CAS: 203866-14-2; (2S,4R)-1-(Tert-Butoxycarbonyl)-4-Fluoropyrrolidine-2-Carboxylic Acid

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N-Boc-顺式-4-羟基-L-脯氨酸甲酯置于二乙胺基三氟化硫,水,Sodium Hydroxide体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应生成N-Boc-反式-4-氟-L-脯氨酸
参考文献:Novel Amino Pyrimidine Derivatives
标题:Novel Amino Pyrimidine Derivatives
摘要:本发明描述了新的氨基嘧啶衍生物及其药用盐,这些衍生物似乎与布鲁顿酪氨酸激酶(btk)相互作用.因此,这些新型氨基嘧啶可能在治疗自身免疫性疾病,炎症性疾病,过敏性疾病,气道疾病(如哮喘和慢性阻塞性肺病(copd)),移植排斥,血液起源或实体肿瘤等癌症方面具有有效性.

专利信息

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7169932-B2
优先权日:2001-06-11
标题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:PFIZER
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.

专利号:CN-112194606-A
优先权日:2019-07-08
标题 :A kind of N-BOC-cis-4-hydroxyproline methyl ester synthesis technology