CAS: 192818-73-8; 1-[(E)-2-Nitroethenyl]-2-(Trifluoromethyl)Benzene

上下游产品

2-(三氟甲基)肉桂酸 (E)-3-(2-(Trifluoromethyl)Phenyl)Acrylic Acid 98386-81-3

📜2-(三氟甲基)肉桂酸置于三甲基氯硅烷,Copper(II) Nitrate Trihydrate体系中,用 乙腈 用作溶剂,化学反应 2.0H,反应生成反式-β-硝基-2-(三氟甲基)苯乙烯
参考文献:氯/溴三甲基硅烷-铜(no 3)2 .3H 2 ○:安全有效的试剂系统的脱羧本位-Nitration和肉桂酸二溴化
标题:氯/溴三甲基硅烷-铜(no 3)2 .3H 2 ○:安全有效的试剂系统的脱羧本位-Nitration和肉桂酸二溴化
摘要:揭示了卤代三甲基硅烷-硝酸盐混合物的进一步合成潜力.Tmsx-Cu构成(no的混合物3)2 .3H 2 O系统被发现是两者的脱羧硝化的有效试剂系统(本位-Nitration)当x = Cl和的肉桂酸,与x = Br的二溴化,在温和的条件下.该反应是安全且简单的,可以在相对较短的时间内以高收率高产率获得相应的产物(e)-β-硝基苯乙烯和抗-2,3-二溴-3-苯基丙酸.可以避免使用有害和有毒的硝化系统,例如硝酸硝酸乙酰酯和溴化剂,例如分子溴.
Doi:10.1016/j.Tetlet.2017.06.017

专利信息

专利号:US-2010010219-A1
优先权日:2006-12-07
标 题 :Method for producing pyrrolidine compound
发明人：HARADA KAZUHITO; ITO TAKASHI
权利人:JAPAN TOBACCO INC
摘要:Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. n A method of producing a compound represented by the following formula [8]: n n n n n n n n n n or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: n n n n n n n n n n or a reactive derivative thereof, or a salt thereof, or a solvate thereof.