CAS: 188815-30-7; 3-Fluoro-5-(Trifluoromethyl)Benzaldehyde

上下游产品

3-Trifluoromethylbenzaldehyde N-{5-ethyl-4-[(3-fluoro-5-trifluoromethyl-phenyl)-hydroxy-methyl]-2-methoxy-6-methyl-pyridin-3-yl}-2,2-dimethyl-propionamideN-{5-ethyl-4-[(3-fluoro-5-trifluoromethyl-phenyl)-hydroxy-methyl]-2-methoxy-6-methyl-pyridin-3-yl}-2,2-dimethyl-propionamide trans 3-(3-trifluoromethyl-5-fluorophenyl)-2-propenoic acid methyl ester H-pyridin-2-one3-amino-5-ethyl-4-(3-fluoro-5-trifluoromethyl-benzoyl)-6-methyl-1H-pyridin-2-one N-[5-ethyl-4-(3-fluoro-5-trifluoromethyl-benzoyl)-2-methoxy-6-methyl-pyridin-3-yl]-2,2-dimethyl-propionamideN-[5-ethyl-4-(3-fluoro-5-trifluoromethyl-benzoyl)-2-methoxy-6-methyl-pyridin-3-yl]-2,2-dimethyl-propionamide

3-三氟甲基苯甲醛置于fluorine体系中,用 乙腈 用作溶剂,以24%的收率获得3-氟-5-(三氟甲基)苯甲醛
参考文献:元素氟.第21部分.(1)苯甲醛衍生物的直接氟化
标题:元素氟.第21部分.(1)苯甲醛衍生物的直接氟化
摘要:一系列苯甲醛衍生物的直接氟化产生氟苯甲醛和苯甲酰氟产物的混合物,其比例取决于环取代基的性质.吸电子取代基主要产生苯甲酰氟衍生物,而供电电子取代基形成氟芳烃体系.通过苯甲酰氟副产物的酯化可以容易地完成环氟化产物的分离.使用连续流技术也已经实现了这些方法的规模化,以提供大量合适的氟苯甲醛体系.
Doi:10.1021/op700194R

专利信息

专利号:US-4399240-A
优先权日:1981-12-30
标 题:Removal of acrylonitrile from latex with saturated heterocyclic amines
发明人：SENYEK MICHAEL L
权利人:GOODYEAR TIRE & RUBBER
摘要:Acrylonitrile is a monomer that is widely used in the synthesis of a vast variety of polymers. Undesirable quantities of unpolymerized residual acrylonitrile are often present in these acrylonitrile polymers. This residual or free acrylonitrile dissolved in an acrylonitrile polymer and/or its emulsifier system and the water phase used in its polymerization can be reduced significantly in concentration by treatment with saturated 6 to 7 membered ring heterocyclic amines. These amines react with acrylonitrile by a nitrogen-cyanoethylation reaction which results in the formation of a tertiary amino linkage.

专利号:US-4365027-A
优先权日:1981-12-28
标 题 :Removal of acrylonitrile from latex with oximes
发明人：SENYEK MICHAEL L; COSTANZA ALBERT J
权利人:GOODYEAR TIRE & RUBBER
摘要:Acrylonitrile is a monomer that is widely used in the synthesis of a vast variety of polymers. Undesirable quantities of unpolymerized residual acrylonitrile are often present in these acrylonitrile polymers. This residual or free acrylonitrile dissolved in an acrylonitrile polymer and/or its emulsifier system and the water phase used in its polymerization can be reduced significantly in concentration by treatment with oximes. Oximes react with acrylonitrile by an oxygen-cyanoethylation reaction which results in the formation of a cyanoethyl oximino ether linkage.

专利号:US-5756606-A
优先权日:1997-05-22
标题:Means to control particle size and eliminate fouling in the synthesis of syndiotactic 1,2 - polybutadiene
发明人：WONG TANG HONG
权利人:GOODYEAR TIRE & RUBBER
摘要:Syndiotactic 1,2-polybutadiene is a thermoplastic resin which has double bonds attached in an alternating fashion to its polymeric backbone. Films, fibers and molded articles can be made utilizing syndiotactic 1,2-polybutadiene. It can also be blended into rubbers and cocured therewith. It is generally preferred to synthesize syndiotactic 1,2-polybutadiene in an aqueous medium by suspension or emulsion polymerization. In such aqueous polymerization techniques reactor fouling and particle size control problems are frequently encountered. This invention is based upon the unexpected finding that reactor fouling can be greatly reduced or eliminated and that particle size can be regulated by conducting such aqueous polymerizations in the presence of a controlled amount of dissolved oxygen which is within the range of about 0.01 ppm to about 4 ppm. This invention more specifically discloses a process for preparing syndiotactic 1,2-polybutadiene in an aqueous medium with minimal reactor fouling which comprises polymerizing 1,3-butadiene monomer in the aqueous medium in the presence of (1) a catalyst system which is comprised of (a) transition metal compound, (b) an organoaluminum compound and (c) at least one member selected from the group consisting of carbon disulfide, phenyl isothiocyanate and xanthic acid and (2) from about 0.01 ppm to about 4 ppm of oxygen.\\!

专利号:US-5986026-A
优先权日:1997-05-05
标 题:Syndiotactic 1,2-polybutadiene synthesis
发明人：WONG TANG HONG; CLINE JAMES HEBER
权利人:GOODYEAR TIRE & RUBBER
摘要:Syndiotactic 1,2-polybutadiene is a thermoplastic resin which has double bonds attached in an alternating fashion to its polymeric backbone. Films, fibers and molded articles can be made utilizing syndiotactic 1,2-polybutadiene. It can also be blended into rubbers and cocured therewith. In such applications, sometimes it is beneficial for the syndiotactic 1,2-polybutadiene to have more than one melting point. This invention discloses a process for preparing syndiotactic 1,2-polybutadiene having at least two different melting points which comprises: polymerizing 1,3-butadiene monomer in an aqueous medium in the presence of (1) a catalyst composition which is made by reacting (a) at least one cobalt compound selected from the group consisting of (i) beta -diketone complexes of cobalt, (ii) beta -keto acid ester complexes of cobalt, (iii) cobalt salts of organic carboxylic acids having 6 to 15 carbon atoms and (iv) complexes of halogenated cobalt compounds of the formula CoXn, wherein X represents a halogen atom and n represents 2 or 3, with an organic compound selected from the group consisting of tertiary amine alcohols, tertiary phosphines, ketones and N,N-dialkylamides, (b) at least one organoaluminum compound of the formula AlR3, wherein R represents a hydrocarbon radical of 1 to 6 carbon atoms and (c) at least one conjugated diene; (2) at least one member selected from the group consisting of carbon disulfide, phenyl isothiocyanate and xanthic acid; and (3) at least one melting-point regulator and (4) a sodium halide salt or a potassium halide salt.

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:US-5011896-A
优先权日:1990-09-10
标 题:Syndiotactic 1,2-polybutadiene synthesis in an aqueous medium
发明人：BELL ANTHONY J; OFSTEAD EILERT A
权利人:GOODYEAR TIRE & RUBBER
摘要:Pure syndiotactic 1,2-polybutadiene is a thermoplastic resin which has double bonds attached in an alternating fashion to its polymeric backbone. Films, fibers and molded articles can be made utilizing syndiotactic 1,2-polybutadiene. It can also be blended into rubbers and cocured therewith. Syndiotactic 1,2-polybutadiene can be made by solution, emulsion or suspension polymerization. It typically has a melting point which is within the range of about 195° C. to about 215° C. However, it is often desirable for the syndiotactic 1,2-polybutadiene to have a melting point of less than about 195° C. This invention discloses a process for preparing syndiotactic 1,2-polybutadiene having a melting point of less than about 195° C. which comprises: polymerizing 1,3-butadiene monomer in an aqueous medium in the presence of (1) a catalyst composition which is made by reacting (a) at least one cobalt compound (b) at least one organoaluminum compound, and (c) at least one conjugated diene; (2) carbon disulfide; and (3) at least one modifier selected from the group consisting of (a) 4-(alkylamino)benzaldehydes, (b) 4-(dialkylamino)benzaldehydes, (c) 2,4-di-(alkoxy)benzaldehydes, (d) 2,6-di-(alkoxy)benzaldehydes, (e) 2,4,6-tri-(alkoxy)benzaldehydes, and (f) 4-(1-azacycloalkyl)benzaldehydes.