专利号:WO-2023227996-A1 优先权日:2022-05-24 标题 :A deuterated amine compounds and process for synthesis thereof 发明人:AMBATI VIJAY; KOTHARI MANISH; JONNALAGADDA NAGASIVARAO; ALETI RANJITH; KANDASAMY DR SAKHTIVEL; ROHIT CHITTALURI KRISHNA; REDDY KATUKURI MALLIKHARJUNA 权利人:CLEARSYNTH LABS LTD 摘要:The present invention relates to a process for synthesis of a deuterated compound. Most particularly, it relates to synthesis of a deuterated amine compounds of formula (l) and salts thereof. The said compound is an important key intermediate in the synthesis of deuterated drugs and/or chemical compounds.
专利号:WO-2025078335-A1 优先权日:2023-10-09 标 题 :Processes for the preparation of deucravacitinib 发明人:ETAYO PÉREZ PABLO; PUJOL OLLÉ XAVIER; MOLINA NIETO JUAN 权利人:FARMHISPANIA GROUP S L 摘要:The invention relates to processes for the preparation of deucravacitinib of formula (XI), or a pharmaceutically acceptable salt thereof. It also relates to intermediates of formula (V') and (V'') as defined herein useful in the synthesis of this molecule.
专利号:US-12390420-B1 优先权日:2024-10-22 标题 :Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof 发明人:EGUCHI MASAKATSU 权利人:BRYET US INC 摘要:The present disclosure provides compositions and methods for delivering therapeutic agents to particular tissues or cells in a subject. The composition disclosed herein combines unique properties of porous micro- or nano-particles with host-guest chemistry provided by functionalized silicon particle, offering a versatile approach to addressing the challenges associated with delivering therapeutic agents to target tissues or sites within the body. The present disclosure also provides a method for synthesizing a composition capable of delivering therapeutic agents to particular tissues or cells in a subject.
1: Papp K, Gordon K, Thaçi D, Morita A, Gooderham M, Foley P, Girgis IG, Kundu S, Banerjee S. Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis. N Engl J Med. 2018 Oct 4;379(14):1313-1321. doi: 10.1056/NEJMoa1806382. Epub 2018 Sep 11. https://acrabstracts.org/abstract/bms-986165-is-a-highly-potent-and-selective-allosteric-inhibitor-of-tyk2-blocks-il-12-il-23-and-type-i-interferon-signaling-and-provides-for-robust-efficacy-in-preclinical-models-of-systemic-lupus-e/. Accessed November 7, 2018.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).