CAS: 148461-16-9; (S)-4-(Tert-Butyl)-2-(2-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole

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CAS号154701-60-7 (S)-2-(2-Bromop... | CAS号829-85-6 二苯基膦 | CAS号112245-13-3 (S)-叔亮氨醇 | CAS号7154-66-7 2-溴苯甲酰氯 | CAS号402755-63-9 2-bromo-N-[(2S)... | CAS号150255-49-5 4-tert-butyl-2-... | CAS号15475-27-1 二苯基磷酸钾 | CAS号394-47-8 2-氟苯甲腈 | CAS号393-52-2 邻氟苯甲酰氯 | CAS号179116-92-8 (S)-2-fluoro-N-...

2-氟苯腈置于zinc(II) Chloride体系中,用 四氢呋喃,氯苯 用作溶剂,化学反应 50.0H,反应生成(S)-4-叔丁基-2-[2-(二苯基膦基)苯基]-2-噁唑啉
参考文献:新型含硫和磷的恶唑啉作为配体的不对称催化反应
标题:新型含硫和磷的恶唑啉作为配体的不对称催化反应
摘要:描述了同时包含恶唑啉基团和另外的硫或磷供体原子的对映体纯的配体的制备.一步法制得了甲硫基甲基,邻硫代茴香基和噻吩基恶唑啉,并分两步从可商购的起始原料中以高收率制备了邻二苯基膦基苯基恶唑啉.
Doi:10.1016/s0040-4020(01)80795-X

专利信息

专利号:US-9518034-B2
优先权日:2013-10-14
标题 :Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
发明人：STOLTZ BRIAN M; DOUGHERTY DENNIS A; DUQUETTE DOUGLAS; DUFFY NOAH
权利人:CALIFORNIA INST OF TECHN
摘要:This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n ncomprising treating a compound of formula (II):n n nwith a transition metal catalyst under alkylation conditions.

专利号:US-11377396-B2
优先权日:2014-12-18
标题 :Enantioselective synthesis of α-quaternary Mannich adducts by palladium-catalyzed allylic alkylation
发明人：STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; PRITCHETT BEAU P; CHIYODA KOJI
权利人:CALIFORNIA INST OF TECHN
摘要:This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n ncomprising treating a compound of formula (II):n n nwith a transition metal catalyst under alkylation conditions.

专利号:US-2016096810-A1
优先权日:2014-10-07
标 题 :Enantioselective synthesis of dialkylated n,o-heterocycles by palladium-catalyzed allylic alkylation
发明人：STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; BEHENNA DOUGLAS C
权利人:STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; BEHENNA DOUGLAS C
摘要:This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n n n n n n n n n n comprising treating a compound of formula (II): n n n n n n n n n n with a transition metal catalyst under alkylation conditions.

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

专利号:US-2020157020-A1
优先权日:2014-12-18
标题:Enantioselective synthesis of alpha-quaternary mannich adducts by palladium-catalyzed allylic alkylation

专利号:US-2015105552-A1
优先权日:2013-10-14
标 题 :Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof