CAS: 148-53-8; 2-Hydroxy-3-Methoxybenzaldehyde

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CAS号2591-86-8 1-甲酰哌啶 | CAS号217813-03-1 三氟甲烷磺酸3-甲氧基-2-(... | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号5464-77-7 N,N-二苄基甲酰胺 | CAS号123-39-7 N-甲基甲酰胺 | CAS号24677-78-9 2,3-二羟基苯甲醛 | CAS号74-88-4 碘甲烷 | CAS号2169-99-5 2-羟基-3-甲氧基苯甲醛肟 | CAS号548756-56-5 tert-butyl 3-hy... | CAS号107189-08-2 3-(苯甲酰基氧基)-2-羟基苯甲酸 | CAS号102234-44-6 2-乙基-7-甲氧基苯并呋喃 | CAS号106052-58-8 2-methoxy-6-[[(... | CAS号110124-13-5 3-methoxy-2-(2-... | CAS号107188-74-9 (-)-(S)-5-溴-2,3... | CAS号111844-11-2 6-[[(6-aminopyr... | CAS号5768-39-8 1,3-亚甲二氧杂环戊烯-4-羧酸 | CAS号50551-58-1 7-甲氧基苯并呋喃-2-甲酸乙酯 | CAS号42973-56-8 2-羟基-3-甲氧基苯乙腈 | CAS号5653-62-3 2,3-二甲氧基苯甲腈

2,3-二甲氧基苯甲醛置于lithium Chloride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 22.0H,以98%的收率获得邻香草醛
参考文献:Dealkylation Of Activated Alkyl Aryl Ethers Using Lithium Chloride In Dimethylformamide
标题:Dealkylation Of Activated Alkyl Aryl Ethers Using Lithium Chloride In Dimethylformamide
摘要:在邻位或对位含有吸电子取代基的烷基芳基醚,在二甲基甲酰胺中能被氯化锂轻易裂解.
Doi:10.1055/s-1989-27225

专利信息

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:US-3972945-A
优先权日:1974-12-23
标 题:Process for the selective synthesis of salicylaldehydes
发明人：ALBRIGHT CHARLES F
权利人:GARRETT CORP
摘要:The classical Reimer-Tiemann reaction for the synthesis of phenolic aldehydes has been modified from an aqueous to a non-aqueous system to provide an improved route for the formation of salicylaldehydes and, preferably, 3-substituted salicylaldehydes, e.g. 3-fluorosalicylaldehyde. Heretofore, compounds such as 3-substituted salicylaldehydes have proven to be extremely difficult to prepare in other than small laboratory quantities from the corresponding ortho-substituted phenol, since, in the final salicylaldehyde, each position ortho to the hydroxyl group contains substitution. In particular, with respect to 3-fluorosalicylaldehyde, one of the positions is occupied by the strongly electronegative fluorine atom so that the principal reaction product in the aqueous Reimer-Tiemann reaction has always been the para-isomer (3-fluoro-4-hydroxy-benzaldehyde), only negligible quantities of the desired ortho-isomer being obtained. In the process of the present invention, o-fluorophenol is caused to react with sodium hydroxide and chloroform in a hydrocarbon diluent (preferably benzene), maintaining the reaction under essentially anhydrous conditions by taking up the water of reaction with excess sodium hydroxide. It is necessary that an aprotic solvent, such as N,N-dimethylformamide, be employed as a catalyst. The use of boron oxide, while not absolutely necessary to the reaction, has been found to be advantageous in that the reaction proceeds more smoothly if the phenoxyboroxine is formed initially. The boron oxide also acts as a dehydrating agent and aids in removing the water of reaction. The preferential reaction product is the desired 3-fluorosalicylaldehyde, no paraisomer having been found. After hydrolysis and neutralization, the 3-fluorosalicylaldehyde can be recovered by azeotropic distillation along with a substantial quantity of unreacted o-fluorophenol which can be purified for recycle in subsequent preparations.

专利号:US-8674119-B2
优先权日:2010-07-16
标题 :Chemical processes for the manufacture of substituted benzofurans
发明人：FLYNN BERNARD LUKE
权利人:FLYNN BERNARD LUKE; BIONOMICS LTD
摘要:The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesis of a particular class of substituted benzofuran tubulin polymerisation inhibitors.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-2004097717-A1
优先权日:2000-03-24
标 题:Control of aerial branching
发明人：LEYSER OTTOLINE; BOOKER JONATHAN; SOREFAN KARIM
摘要:A plant nucleic acid sequence is provided which encodes a protein involved in the synthesis of abscisic acid. The plant nucleic acid sequence, and proteins encoded thereby, are useful in the regulation of aerial branching in plants.

专利号:US-7935704-B2
优先权日:2003-08-01
标 题 :Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人：PALLADINO MICHAEL A; LLOYD GEORGE KENNETH; HAYASHI YOSHIO; NICHOLSON BENJAMIN
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ″, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.