CAS: 144-82-1; 4-Amino-N-(5-Methyl-1,3,4-Thiadiazol-2-yl)Benzenesulfonamide

该化合物是活动范围狭窄的磺酰胺抗生素,主要针对克阴性细菌,其化学结构的特点是硫化氮环,与早先的磺酰胺相比,提高了溶性和生物利用率;该化合物抑制了二氢乙酸盐合成酶,干扰了叶酸合成,防止了微生物生长;硫化物由于其高肾排泄和尿液浓度,对尿道感染特别有效;其快速吸收和相对较短的半衰期允许灵活剂量疗程.尽管在更广泛地使用磺酰胺的情况下出现了抗药性,但硫酸甲醚在具体迹象中仍然具有临床相关性,因为其药用基因特征比新制剂更有利.该药物通常以药片或悬浮剂口服方式使用.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号39719-87-4 N-[4-[[(5-methy... | CAS号349621-24-5 N-(5-methyl-1,3... | CAS号121-60-8 对乙酰氨基苯磺酰氯 | CAS号98-74-8 4-硝基苯磺酰氯 | CAS号108-33-8 2-氨基-5-甲基-1,3,4-噻二唑 | CAS号2302-95-6 (1E)-3-amino-1-... | CAS号75-36-5 乙酰氯 | CAS号29817-74-1 Benzenesulfonam... | CAS号29821-96-3 Benzenesulfonam... | CAS号29822-02-4 Benzenesulfonam... | CAS号39719-87-4 N-[4-[[(5-methy...

合成工艺路线路线简述

    📜N-(5-Methyl-1,3,4-Thiadiazol-2-yl)-4-Nitrobenzenesulfonamide置于铁粉 盐酸体系中,用 乙醇,水 用作溶剂,化学反应 3.0H,以100%的收率获得磺胺甲噻二唑
    参考文献: Modulators Of Immunoinhibitory Receptor Pd-1,And Methods Of Use Thereof[fr] Modulateurs Du Récepteur Immunosuppresseur Pd-1 Et Procédés D'Utilisation De Ceux-Ci
    标题: Modulators Of Immunoinhibitory Receptor Pd-1,And Methods Of Use Thereof[fr] Modulateurs Du Récepteur Immunosuppresseur Pd-1 Et Procédés D'Utilisation De Ceux-Ci

    专利信息


    专利号:US-10768157-B2
    优先权日:2015-10-20
    标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
    发明人:KABIR ABUZAR; FURTON KENNETH G
    权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-2024197774-A1
    优先权日:2021-04-16
    标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
    发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
    权利人:UNIV TEXAS
    摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

    专利号:US-8557979-B2
    优先权日:2004-06-10
    标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
    发明人:CHOI WOO-BAEG; KOWALIK EWA
    权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

    专利号:US-10933051-B2
    优先权日:2017-06-09
    标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
    发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Ejrnæs K. Bacterial characteristics of importance for recurrent urinary tract infections caused by Escherichia coli. Dan Med Bull. 2011 Apr;58(4):B4187. Review. Review. Review. Review.
    5: Janknegt R, van den Broek PJ, Kullberg BJ, Stobberingh E. [Choice of antibiotics in uncomplicated cystitis; application of 'system of objectified judgement analysis' (SOJA) method]. Ned Tijdschr Geneeskd. 1999 Dec 4;143(49):2466-71. Review. Dutch. Review. Review. Review. Review. Review. Review. Review.

    合成参考文献


    摘要:Handbook of Analytical Toxicology, Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969, -(111), 1969
    摘要:Medical Economics Co; Physicians Desk Reference: Generics 2nd ed p.2825 (1996)
    摘要:Smedley MD, Weber JD; J Assoc Off Anal Chem 73: 875-879 (1990). As cited in: Lunn G; HPLC and CE Methods for Pharmaceutical Analysis. CD-ROM. New York, NY: John Wiley & Sons (2000)
    摘要:
    摘要:Olson, K.R. (Ed.); Poisoning & Drug Overdose. 5th ed. Lange Medical Books/McGraw-Hill. New York, N.Y. 2007., p. 82
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知