CAS: 13626-59-0; 3-Methoxyisoxazole-5-Carboxylic Acid

相似化合物

10068-07-2 16880-11-8 35166-36-0

上下游产品

methanol 3-bromo-5-isoxazolecarboxylic acid 3-chloro-5-isoxazolecarboxylic acid 3-methoxyisoxazole-5-carboxylic acid methyl ester 3-methoxyisoxazole-5-carboxylic acid methyl ester 3-methoxy-5-isoxazolecarboxylic acid chloride 3-methoxy-5-hydroxymethylisoxazole 5-aminomethyl-3-methoxyisoxazole

📜甲基3-甲氧基-1,2-恶唑-5-羧酸酯置于sodium Hydroxide,水,盐酸体系中,用 N,N-二甲基甲酰胺,水 用作溶剂,化学反应 0.5H,反应生成3-甲氧基异恶唑-5-甲酸
参考文献:Practical Synthesis Of A Potent Bradykinin B1 Antagonist Via Enantioselective Hydrogenation Of A Pyridyl N-Acyl Enamide
标题:Practical Synthesis Of A Potent Bradykinin B1 Antagonist Via Enantioselective Hydrogenation Of A Pyridyl N-Acyl Enamide
摘要:A Practical And Efficient Synthesis Of Bradykinin B I Antagonist I Is Described. A Convergent Strategy Was Utilized Which Involved Synthesis Of Three Fragments: 3,6,And 7. Cross Coupling Of Fragments 6 And 7 Followed By Amidation With 3 Enabled Efficient Synthesis Of I In 19 Steps Total,A 35% Overall Yield From Commercially Available Pyridine 10. The Key To The Success Of The Synthesis Was The Development Of A Fluorodenitration Step To Install The Fluorine In Pyridine 7 And A Catalytic Enantioselective Hydrogenation Of N-Acyl Enamide 9 To Set The Stereochemistry.
Doi:10.1021/jo802772D

专利信息

专利号:US-5675008-A
优先权日:1992-09-03
标 题 :Excitatory amino acid receptor antagonists
发明人：BERTSCH CARL F; HUFF BRET; MARTINELLI MICHAEL J; ORNSTEIN PAUL L
权利人:LILLY CO ELI
摘要:This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.