CAS: 13280-60-9; 5-Amino-2-Nitrobenzoic Acid

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35998-96-0 610-74-2 77376-03-5

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2-Nitro-5-[[4-[[4-[(2-Phenylacetyl)Amino]Phenyl]Methoxycarbonylamino]Phenyl]Methoxycarbonylamino]Benzoic Acid置于penicillin-G-Amidase体系中,化学反应生成5-氨基-2-硝基苯甲酸
参考文献:消除氮杂醌的方法:生理条件下1,6-和1,4-消除的比较研究.
标题:消除氮杂醌的方法:生理条件下1,6-和1,4-消除的比较研究.
摘要:消除氮杂醌是一个强大而有效的反应,可用于拆解前药系统中的间隔基.我们和其他人已经使用间隔子技术来开发树突状和聚合的自消灭分子系统,这些系统可以在刺激事件发生时通过类似多米诺的机制进行分解.在本报告中,我们研究了可通过对位和邻位氮杂醌甲基化物消除而分解的系统的分解.用经历单个1,6-或1,4-消除的分子和经历双重1,6-和1,4-消除的分子评估拆卸.在生理条件下,1,6-消除比1,4-消除略快.这项研究揭示了前药系统的拆卸行为.
Doi:10.1039/b808198K

专利信息

专利号:US-5115099-A
优先权日:1988-06-14
标 题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
发明人：KUROIWA KATSUMASA; MATSUURA HITOSHI; KATAYAMA KATSUHIRO; NAKATSUYAMA SHUICHI; NAGASAWA TAKESHI; ENDO KOJI
权利人:NITTO BOSEKI CO LTD
摘要:Novel compounds represented by the following formula: ##STR1## wherein A represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides by a novel process comprising a selective deprotection step whereby the protecting group on the α-amine group of arginine is removed in the presence of a hydrochloric acid, acetic acid and dimethylformamide mixture, but a tert-alkyl protecting group on the --COOH group of the nitroanilide ring is not removed by this step.

专利号:EP-3431490-B1
优先权日:2017-07-17
标 题:Chemical compounds for use as diagnostic markers of inflammation and neoplams, the method for synthesis of the chemical compounds, diagnostic kit for use in diagnosis of inflammatory processes and epithelial neoplasms and in vitro diagnostic method of inflammatory processes and epithelial neoplasms
发明人：LESNER ADAM; GRUBA NATALIA
权利人:UNIV GDANSKI

专利号:EP-3431490-A1
优先权日:2017-07-17
标题 :Chemical compounds for use as diagnostic markers of inflammation and neoplams, the method for synthesis of the chemical compounds, diagnostic kit for use in diagnosis of inflammatory processes and epithelial neoplasms and in vitro diagnostic method of inflammatory processes and epithelial neoplasms

专利号:WO-2025082311-A1
优先权日:2023-10-16
标题:Solid-phase simple synthesis method for peptidol
发明人：KAO CHAI-LIN; CHEN HUI-TING; CHEN SZU-HSUAN
权利人:UNIV KAOHSIUNG MEDICAL
摘要:A 3,4-diaminobenzoic acid (Dbz) group on a resin is activated by means of isoamyl nitrite to form benzotriazole (Bt), and a reduction reaction is then performed by using sodium borohydride (NaBH4) as a reducing agent. A peptidol can be obtained by means of a rapid reaction and only a simple filtering method; and the generation of by-products accompanying with the reaction can be reduced by changing conditions.

专利号:EP-0513863-A1
优先权日:1988-06-14
标题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates

专利号:EP-0513863-B1
优先权日:1988-06-14
标题:Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates