CAS: 122-48-5; 4-(4-Hydroxy-3-Methoxyphenyl)-2-Butanone

该化合物是一种自然产生的有机化合物,其特点是能够抑制COX-2酶,减少炎症,其抗氧化特性也为抗氧化应激和细胞损伤提供了保护,该化合物在开发抗炎和抗氧化疗法方面可能具有潜在用途.

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39728-80-8 170467-02-4 122-48-5

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CAS号1080-12-2 脱氢姜酮 | CAS号121-33-5 香草醛 | CAS号78-94-4 丁烯酮 | CAS号90-05-1 愈创木酚 | CAS号61152-59-8 4-hydroxy-4-(4-... | CAS号39886-78-7 4-(4-(苄氧基)-3-甲氧... | CAS号458-36-6 4-羟基-3-甲氧基肉桂醛 | CAS号290820-47-2 (2E)-3-[4-[[ter... | CAS号39728-80-8 4-(3-羟基丁基)-2-甲氧基苯酚 | CAS号77334-06-6 1-(4-hydroxy-3-... | CAS号77398-90-4 5-hydroxy-1-(4-... | CAS号56700-87-9 4-[3-Methoxy-4-... | CAS号61152-58-7 4-(3-hydroxybut... | CAS号61152-62-3 4-(3,4-二羟基苯基)-2-丁酮 | CAS号6302-60-9 2-Butanone,4-(3...

合成工艺路线路线简述

  • 合成目标产物 Vanillylacetone 主要起始原料 Vanillylidenacetone
  • (文献来源)合成步骤主要原料 Vanillylidenacetone
4-((Tert-Butyldiphenylsilyl)Oxy)-3-Methoxybenzyl 3-Oxobutanoate置于四丁基氟化铵,Zinc(II) Chloride体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 0.75H,以70%的收率获得姜酮
参考文献:脱羧的csp3-Csp3偶联,用于不稳定的酮烯醇酯的苯甲酸酯化:对-(酰基乙基)苯酚的合成
标题:脱羧的csp3-Csp3偶联,用于不稳定的酮烯醇酯的苯甲酸酯化:对-(酰基乙基)苯酚的合成
摘要:已经开发出一种新的用于羧甲基化烯醇烯酸酯的脱羧csp3-Csp3偶联方法.在高温条件下,可以方便地合成多种树莓酮衍生物,并具有非常好的收率.
Doi:10.1039/c6Cc03835B

海关参考信息

专利信息


专利号:US-9943544-B2
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
发明人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人:PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:WO-2017071871-A1
优先权日:2015-10-27
标题:Synthesis of ketone releasing photo-cages
发明人:GERKE THOMAS; KROPF CHRISTIAN; HUCHEL URSULA; GRIESBECK AXEL; LANDES AGNIESZKA
权利人:HENKEL AG & CO KGAA
摘要:The invention relates to the production of specific ketones of formulae (I) and (VI), as defined herein, which act as photolabile pro-fragrances.

专利号:US-11976052-B2
优先权日:2019-01-11
标题:Leukotriene synthesis inhibitors
发明人:BURGOYNE DAVID L; DEBRUIN ERIN; FONAREV JULIA; YEE JAMES GEE KEN; LANGLANDS JOHN MICHAEL
权利人:NAEGIS PHARMACEUTICALS INC
摘要:Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseases or conditions.

专利号:US-2016271177-A1
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer

专利号:EP-2897906-A1
优先权日:2012-09-20
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
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主要参考文献


1: Mahesha H, Prashanth KVH, Bettadaiah BK. The bioconjugates of curcumin, zingerone and [6]-shogaol with low molecular weight chitosan: Synthesis, characterization and in vitro anticancer activity in HepG2 cells. Int J Biol Macromol. 2025 Jan 11;296:139785. doi: 10.1016/j.ijbiomac.2025.139785. Epub ahead of print. 35(1):101527. doi: 10.1016/j.mycmed.2024.101527. Epub ahead of print. 14(12):693. doi: 10.3390/metabo14120693.
4: Famurewa AC, Akhigbe RE, George MY, Adekunle YA, Oyedokun PA, Akhigbe TM, Fatokun AA. Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec 5. doi: 10.1007/s00210-024-03623-5. Epub ahead of print. 38(12):e70074. doi: 10.1002/jbt.70074. 194 Suppl
1:115116. doi: 10.1016/j.fct.2024.115116. Epub 2024 Nov 17.

合成参考文献


参考文献:10.1007/s11064-011-0548-5
摘要:Kabuto H, Yamanushi TT. Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model. Neurochem Res. 2011 Dec;36(12):2244–9. doi: 10.1007/s11064-011-0548-5.
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