CAS: 1072-84-0; 1H-Imidazole-4-Carboxylic Acid

相似化合物

5317-07-7 191103-80-7 676372-30-8

上下游产品

CAS号822-55-9 4-(羟甲基)咪唑 | CAS号2302-25-2 4-溴-1H-咪唑 | CAS号2258-42-6 甲乙酐 | CAS号288-32-4 咪唑 | CAS号570-22-9 咪唑-4,5-二羧酸 | CAS号13189-13-4 1H-Imidazole-5-... | CAS号3465-72-3 反式尿刊酸 | CAS号40507-59-3 4-硝基-1H-咪唑-5-羧酸 | CAS号20271-20-9 5-硝基咪唑-4-甲酸甲酯 | CAS号288-32-4 咪唑 | CAS号822-55-9 4-(羟甲基)咪唑 | CAS号53525-65-8 咪唑并[1,5-a:1',5'... | CAS号1746-25-4 2,4,5-三碘-1H-咪唑 | CAS号17325-26-7 咪唑-4-甲酸甲酯 | CAS号23785-21-9 咪唑-4-甲酸乙酯 | CAS号191103-80-7 1-三苯甲基-1H-咪唑-4-羧酸

咪唑-4,5-二羧酸置于乙酸酐体系中,化学反应 5.0H,以80%的收率获得1H-咪唑-4-甲酸
参考文献:新型咪唑类化合物的合成和合成孔径雷达是一种具有高结合效率的强效和选择性大麻素cb 2受体拮抗剂
标题:新型咪唑类化合物的合成和合成孔径雷达是一种具有高结合效率的强效和选择性大麻素cb 2受体拮抗剂
摘要:描述了咪唑的合成及其构效关系.目标化合物6-20表示的新颖的化学类型有效的和cb 2 / Cb 1选择性大麻素cb 2受体拮抗剂/反向激动剂在具有有利的日志组合非常高结合效率 P和计算的极性表面积值. 在该系列中,化合物12表现出最高的cb 2受体亲和力(k I = 1.03 Nm)以及最高的cb 2 / Cb 1亚型选择性(> 9708倍).
Doi:10.1016/j.Bmcl.2009.12.032

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-4921955-A
优先权日:1987-11-06
标 题 :Process for the synthesis of 1-substituted imidazole-5-carboxylic acids and carboxylic acid derivatives
发明人：TOEPFL WERNER
权利人:CIBA GEIGY CORP
摘要:The invention relates to a process for the preparation of 1,5-disubstituted imidazoles of the formula (I) by alkylation of an N-cyanoformamidine of the formula II X-NH-CH=N-CH (II) to form an N,N-disubstituted N'-cyanoformamidine of the formula (IV) which is cyclised under the action of bases to form a 4-aminoimidazole of the formula (V) and then reduced to form the product of the formula I. The invention relates also to a special process for the reduction of the aminoimidazole V to I, and to intermediate compounds for carrying out this process and to processes for the preparation of the intermediate compounds. The meaning of the substituents X and L is explained in detail in the text.

专利号:US-5750692-A
优先权日:1990-01-11
标 题 :Synthesis of 3-deazapurines
发明人：COOK P DAN; ACEVEDO OSCAR L; ANDREWS ROBERT S
权利人:ISIS PHARMACEUTICALS INC
摘要:This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of 'antisense' agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.