CAS: 106402-41-9; H-Ser-Otbu.Hcl

该化合物是有机合成和制药研究中广泛使用的一个手动建筑块,该化合物的特点是一个叔丁基酯类和盐盐形式,加强了合成应用的稳定性和溶性.2S)配置确保了立体化学精度,使其对不对称合成和浸泡物的改变具有价值.其氢氧基和氨基功能组为进一步衍生提供了多种再活动.盐改进了处理和储存便利.这种试剂对于培养生物活性分子,包括蛋白抑制剂和其他治疗中间体特别有用.高纯度和一贯质量对于其要求合成工作流程的性能至关重要.

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相似化合物

1033753-14-8 26348-61-8 302-84-1

欧盟法规

C&L通报

合成工艺路线路线简述

    📜N-叔丁氧羰基丝氨酸叔丁酯置于盐酸体系中,用 乙酸乙酯 用作溶剂,化学反应生成L-丝氨酸叔丁酯盐酸盐
    参考文献:Selective Removal Of An N-Boc Protecting Group In The Presence Of A Tert-Butyl Ester And Other Acid-Sensitive Groups
    标题:Selective Removal Of An N-Boc Protecting Group In The Presence Of A Tert-Butyl Ester And Other Acid-Sensitive Groups
    摘要:
    Doi:10.1021/jo00090A045

    海关参考信息

    专利信息


    专利号:US-9175026-B2
    优先权日:2011-03-23
    标题:Synthesis of thioether containing trialkoxysilanes
    发明人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K
    权利人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K; UNIV CALIFORNIA
    摘要:The invention relates to a radical-initiated thiol-ene or thiol-yne “clickâ€? reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “clickâ€? reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes.

    专利号:US-2013345412-A1
    优先权日:2011-03-23
    标 题:Synthesis of thioether containing trialkoxysilanes

    专利号:EP-2688894-A2
    优先权日:2011-03-23
    标题:Synthesis of thioether containing trialkoxysilanes

    专利号:WO-2012129380-A2
    优先权日:2011-03-23
    标题 :Synthesis of thioether containing trialkoxysilanes

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