CAS: 104700-98-3; (R,E)-2-Methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-Pentamethyl-3-Oxo-2,3,4,5,6,10,12,13,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Hept-2-Enal

该化合物是一种与药用蘑菇Ganoderma Coleminum隔离的三叶管化合物,以其潜在的生物活性特性而闻名.在结构上,它被归类为低效类三叶杆,它展示了显著的药理活动,包括抗炎,抗氧化剂和对某些癌症细胞线的细胞毒性影响.它的行动机制可能涉及细胞信号路径的调控,如NF-B和MAPK.Ganoparan A对于研究其潜在的治疗应用,特别是肿瘤学和免疫学方面的应用很感兴趣.HPLC和LC-MS等分析方法通常用于其鉴定和纯度评估.目前还在进行进一步的研究,以阐明其全面的药理学特征和临床相关性.

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    专利信息


    专利号:US-6726911-B1
    优先权日:1999-03-09
    标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239
    发明人:JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI
    权利人:GANOMYCIN
    摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.

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    合成参考文献


    参考文献:10.5281/zenodo.5794106
    摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
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