CAS: 931-16-8; (1R,2R)-2-Aminocyclohexanol

该化合物是具有分子式C6H13NO的乳液,其特征是附于相邻碳原子的环形环形,分别是氨基(-NH2)和氢氧基(-OH),特别是1和2个位置;该化合物的特点是,由于氨基和氢氧基功能组的存在,它能够形成氢联结,这可能影响其在水等极溶剂中的溶解性;1R 2R)-2-Aminocycolenohexanol的立体化学学有助于其生物活动,使其对药物应用感兴趣,特别是各种生物活性化合物的合成;此外,它可以参与各种化学反应,包括矿和酒精反应,这些反应可以在有机合成中加以利用;其物理特性,如熔点和沸点,受到其分子结构和分子相互作用的影响.

英文名称(1R,2R)-2-Aminocyclohexanol
中文名称(1R,2R)-2-氨基环己醇
IUPAC名称(1R,2R)-2-aminocyclohexan-1-ol
其它别名(1R, 2R)-2-Aminocyclohexanol,1R,2R=氨基环己醇; 1R2R反式2氨基环己醇; Trans-2-Aminocyclohexanol
CAS编号931-16-8
MFCD编号:MFCD08061325
EINECS号:804-557-8
分子式:C6H13NO
分子量:115.17
产品CID: 1969870
产品分类有机原料→分子砌块→脂肪环类化合物→环己烷类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: PQMCFTMVQORYJC-PHDIDXHHSA-N
InChI=1S/C6H13NO/c7-5-3-1-2-4-6(5)8/h5-6,8H,1-4,7H2/t5-,6-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数0.0

相似化合物

13374-31-7 5456-63-3 6850-38-0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
严重眼损伤类别1
皮肤腐蚀类别1C
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H314 |造成严重皮肤灼伤和眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264-P270-P273-P280-P304+P340-P330-P391-P501
危险等级9
UN编号3077.0
危险品标志Xn
包装等级Ⅲ
安全声明26-41
危险类别码22-41

欧盟法规

C&L通报

合成工艺路线路线简述

155975-19-2 = 931-16-8
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane
标题:Hybrid Organo- And Biocatalytic Process For The Asymmetric Transformation Of Alcohols Into Amines In Aqueous Medium
作者:Liardo,Elisa; Rios-Lombardia,Nicolas; Moris,Francisco; Rebolledo,Francisca; Gonzalez-Sabin,Javier
参考文献:Acs Catalysis 日期:2017 卷标:7(7) 页码:4768-4774]

141553-09-5 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 1 - 2 H,3 Atm,Rt
标题:An Improved And Efficient Process For The Scalable Preparation Of Optically Pure Trans-2-Aminocyclohexanols
作者:Xue,Feng; Li,Chang-Gong; Zhu,Yong; Lou,Tian-Jun
参考文献:Journal Of Chemical Research 日期:2014 卷标:38(5) 页码:322-324]

141553-09-5 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Rt -> 30 °C; 30 °C
标题:Process For Preparation Of (1R,2R)-2-Benzoxycyclohexanamine
参考文献:China]

98462-58-9 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Ethanol; 12 H,50 Pa
标题:Efficient Ring Opening Of Aziridines With Carboxylic Acids
作者:Kumar,Manoj; Gandhi,Shikha; Kalra,Swinderjeet Singh; Singh,Vinod K.
参考文献:Synthetic Communications 日期:2008 卷标:38(10) 页码:1527-1532]

286-18-0 = 931-16-8
反应条件:1.1 Reagents: Perchloric Acid Solvents: Water
标题:Cyclohexenimine (7-Azabicyclo[4.1.0]Heptane) And The Stereochemistry Of Ethylenimine Ring-Closure And Opening
作者:Paris,Olden E.; Fanta,Paul E.
参考文献:Journal Of The American Chemical Society 日期:1952 卷标:74 页码:3007-10]

110716-78-4 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol
标题:Asymmetric Ring-Opening Of Cyclohexene Oxide With Trimethylsilyl Azide In The Presence Of Titanium Isopropoxide/chiral Ligand
作者:Emziane,M.; Sutowardoyo,K. I.; Sinou,D.
参考文献:Journal Of Organometallic Chemistry 日期:1988 卷标:346(1)]

= 931-16-8 [标题:Reaction Conditions
标题:Preparation Of Optically Active Trans-2-Aminocyclohexanol
参考文献:World Intellectual Property Organization]

= 931-16-8 [标题:Reaction Conditions
标题:Method For Producing Optically Active Trans-2-Aminocyclohexanol And Derivative Thereof
参考文献:World Intellectual Property Organization]

141553-09-5 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 2 H,Rt
标题:Resolution Of Racemic 2-Aminocyclohexanol Derivatives And Their Application As Ligands In Asymmetric Catalysis
作者:Schiffers,Ingo; Rantanen,Toni; Schmidt,Frank; Bergmans,Werner; Zani,Lorenzo; Et Al
参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(6) 页码:2320-2331]

= 931-16-8
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Methanol; 30 Min1.2 Reagents: Hydrogen Catalysts: Platinum Dioxide; 40 H,Rt
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作者:Pendem,Nagendar; Douat,Celine; Claudon,Paul; Laguerre,Michel; Castano,Sabine; Et Al
参考文献:Journal Of The American Chemical Society 日期:2013 卷标:135(12) 页码:4884-4892]

= 931-16-8
反应条件:1.1 Reagents: Ammonia Solvents: Methanol,Water; 0 - 5 °C; Overnight,35 - 40 °C
标题:Preparation Of Tert-Butyl ((1R,2S)-2-Aminocyclohexyl)Carbamate And Benzyl ((1R,2S)-2-Aminocyclohexyl)Carbamate
参考文献:China]

= 931-16-8
反应条件:1.1 Reagents: Ammonia Solvents: Water
标题:Synthesis Of Aminoalcohols From Epoxides And Ammonia
作者:Mcmanus,Samuel P.; Larson,Charles A.; Hearn,Richard A.
参考文献:Synthetic Communications 日期:1973 卷标:3(3) 页码:177-80]

134108-75-1 = 931-16-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol
标题:Opening Of Epoxides With Trimethylsilyl Cyanide To Produce β-Hydroxy Isonitriles. A General Synthesis Of Oxazolines And β-Amino Alcohols
作者:Gassman,Paul G.; Guggenheim,Thomas L.
参考文献:Journal Of The American Chemical Society 日期:1982 卷标:104(21) 页码:5849-50]

110716-78-4 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
标题:Metal(Ii) D-Tartrates Catalyzed Asymmetric Ring Opening Of Oxiranes With Various Nucleophiles
作者:Yamashita,Hiroyuki
参考文献:Bulletin Of The Chemical Society Of Japan 日期:1988 卷标:61(4) 页码:1213-20]

110716-78-4 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
标题:A New Synthesis Of Optically Active Trans-β-Amino Alcohols By Asymmetric Ring-Opening Of Symmetrical Oxiranes
作者:Yamashita,Hiroyuki
参考文献:Chemistry Letters 日期:1987 卷标:(3) 页码:525-8]

98462-58-9 = 931-16-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
标题:Application Of New Chiral Auxiliaries,Trans-2-(N-Arylsulfonyl-N-Benzyl)Cyclohexanols,In An Asymmetric Radical Cyclization
作者:Nishida,A.; Shirato,F.; Nakagawa,M.
参考文献:Tetrahedron: Asymmetry 日期:2000 卷标:11(18) 页码:3789-3805]

139753-27-8 = 931-16-8
反应条件:1.1 Reagents: Sodium Hydroxide,Hydrochloric Acid,Hydrogen Peroxide,Diborane
标题:Synthesis And Reactions Of Organic Compounds With Nitrogen Atom. Part Viii. Action Of Diborane On Some Cyclic O-Acetyl α,β-Unsaturated Aldo- And Ketoximes
作者:Przewoska-Ratajczak,Krystyna; Uzarewicz,Arkadiusz
参考文献:Polish Journal Of Chemistry 日期:1991 卷标:65(5-6) 页码:945-58]

= 931-16-8
反应条件:1.1 Reagents: Phenyl Carbamate Catalysts: Stereoisomer Of [μ-[(4As,27As,31As,54As)-9,23,36,50-Tetrakis(1,1-Dimethylethyl)-...,Stereoisomer Of [μ3-[(4As,27As,31As,54As,58As,81As)-9,23,36,50,63,77-Hexakis(1,1... Solvents: Acetonitrile; 48 H,50 °C; 50 °C -> Rt1.2 Solvents: Dichloromethane; 1 H,Rt1.3 Reagents: Potassium Hydroxide Solvents: Ethanol,Water; 1 Min,Rt; 20 H,85 °C; 85 °C -> Rt1.4 Reagents: Potassium Hydroxide Solvents: Water; Rt1.5 Solvents: Toluene; Heated; Rt; Rt -> 4 °C
标题:A Practical Method For The Synthesis Of Highly Enantioenriched Trans-1,2-Amino Alcohols
作者:Birrell,James A.; Jacobsen,Eric N.
参考文献:Organic Letters 日期:2013 卷标:15(12) 页码:2895-2897]

216586-54-8 = 931-16-8
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Water; 3 H,60 °C
标题:Cyclic Trans-β-Amino Alcohols: Preparation And Enzymatic Kinetic Resolution
作者:Rouf,Abdul; Gupta,Pankaj; Aga,Mushtaq A.; Kumar,Brijesh; Parshad,Rajinder; Et Al
参考文献:Tetrahedron: Asymmetry 日期:2011 卷标:22(24) 页码:2134-2143]

= 931-16-8
反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Dimethylformamide
标题:A Convenient Method For Obtaining Trans-2-Aminocyclohexanol And Trans-2-Aminocyclopentanol In Enantiomerically Pure Form
作者:Overman,L. E.; Sugai,S.
参考文献:Journal Of Organic Chemistry 日期:1985 卷标:50(21) 页码:4154-5