CAS: 870234-98-3; 3,5-Difluoroisonicotinaldehyde

该化合物是一种有机化合物,其特点是存在一种由两种氟原子和甲酰胺功能组组成的环替代的环,分子结构特征是一个含有一个氮原子的六人芳香环,而甲酰胺组则与氮的碳相邻.该化合物一般是无色的,不光色的黄色液体或固体,视其体温的状态而定.该化合物以其反应为己有闻名,因为甲酰胺功能组可以参与各种化学反应,包括核分裂生物学添加物和凝聚反应.氟丁烷原子的存在可增强其电光学特性,并影响其在有机合成中的溶解性和再活性.3,5-二氟-4-丙烯酸酯,对药用化学和材料科学是有兴趣的,因为它可以作为药物或农化化学合成的中间体.应当查阅安全数据,以便处理和储存,作为化学物质.

结构式图片

相似化合物

1214377-09-9 903522-29-2 40273-47-0

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上下游产品

CAS号107-31-3 甲酸甲酯 | CAS号71902-33-5 3,5-二氟嘧啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号625-92-3 3,5-二溴吡啶 | CAS号70201-42-2 3,5-二溴-4-吡啶甲醛

合成工艺路线路线简述

  • 合成目标产物 3,5-Difluoro-4-Pyridinecarboxaldehyde 主要起始原料 Methyl Formate And 3,5-Difluoropyridine
  • 2982877-51-8 = 870234-98-3
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 10 Min,60 °C
    标题:Straightforward Synthesis Of Halopyridine Aldehydes Via Diaminomethylation
    作者:Koidan,Georgyi; Et Al
    参考文献:Chemistry - A European Journal 日期:2023 卷标:29(55)]

    924649-12-7 = 870234-98-3
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,60 °C1.2 Reagents: Sodium Carbonate Solvents: Water; 0 °C2.1 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane; 1 H,Rt
    标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
    作者:Ko,Yoon-Joo; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2006 卷标:127(6) 页码:755-759]

    924649-13-8 = 870234-98-3
    反应条件:1.1 Reagents: Hydrochloric Acid,N-Fluorobenzenesulfonimide Solvents: Water; 2 H,Reflux1.2 Reagents: Sodium Carbonate Solvents: Water; 0 °C
    标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
    作者:Ko,Yoon-Joo; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2006 卷标:127(6) 页码:755-759]

    924649-16-1 = 870234-98-3
    反应条件:1.1 Reagents: Dimethyl Sulfoxide,Oxalyl Chloride Solvents: Dichloromethane; 10 Min,-60 °C1.2 Solvents: Dichloromethane; 20 Min,-60 °C1.3 Reagents: Triethylamine Solvents: Dichloromethane,Water; Rt
    标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
    作者:Ko,Yoon-Joo; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2006 卷标:127(6) 页码:755-759]

    70201-42-2 + 107-21-1 = 870234-98-3
    反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Benzene; 12 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt2.1 Reagents: Hydrochloric Acid,N-Fluorobenzenesulfonimide Solvents: Water; 2 H,Reflux2.2 Reagents: Sodium Carbonate Solvents: Water; 0 °C
    标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
    作者:Ko,Yoon-Joo; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2006 卷标:127(6) 页码:755-759]

    924649-11-6 = 870234-98-3
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 0.5 H,-120 °C1.2 Reagents: N-Fluorobenzenesulfonimide Solvents: Tetrahydrofuran; 3 H,-120 °C1.3 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,60 °C2.2 Reagents: Sodium Carbonate Solvents: Water; 0 °C3.1 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane; 1 H,Rt
    标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
    作者:Ko,Yoon-Joo; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2006 卷标:127(6) 页码:755-759
📜3,5-Dibromo-4-[1,3]Dioxolan-2-Yl-Pyridine置于盐酸体系中,化学反应 2.0H,以90%的收率获得产物3,5-二氟吡啶-4-甲醛
参考文献:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
标题:Synthesis Of Difluorinated Pyridinecarboxaldehyde Via Electrophilic Fluorination
摘要:An Efficient Synthesis Of Novel 3,5-Difluoropyridine-4-Carboxaldehyde Using N-Fluoro-Benzenesulfonimide (Nsfi) Is Described. Difluorination Was Achieved Through The Reaction Of 3,5-Dihalo-1,3-Dioxolane Pyridine With N-Butyllithium Followed By N-Fluorobenzenesulfonimide At-120 Degrees C In Good To High Yields. Maintaining The Low Temperature During The Transmetallation Was Found To Be Critical For The Selective Formation Of The Difluoro-Susbstitution Over The Monofluoro One. (C) 2006 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Jfluchem.2006.02.009

海关参考信息

专利信息


专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.

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合成参考文献


参考文献:10.1055/s-2007-990842
摘要:Rostami A. N-Fluorobenzenesulfonimide [(PhSO2)2NF] - A Neutral N-F-Containing Electrophilic Fluorinating Agent. Synlett. 2007 Oct 12;2007(18):2924–5. doi: 10.1055/s-2007-990842.
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