CAS: 856214-16-9; 4-Hydroxy-2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid

相似化合物

87853-70-1 609-71-2 2091088-67-2

📜6-氯-1,2-二氢-4-羟基-2-氧代-3-吡啶甲腈置于硫酸,锌体系中,化学反应生成 1,2-二氢-4-羟基-2-氧代-3-吡啶羧酸
参考文献:Schroeter Et Al.,Chemische Berichte,1932,Vol. 65,P. 432,441
标题:Schroeter Et Al.,Chemische Berichte,1932,Vol. 65,P. 432,441

专利信息

专利号:US-7807140-B2
优先权日:2006-05-03
标题 :Magnetic resonance imaging contrast agents synthesized using ring-opening metathesis polymerization
发明人：KIESSLING LAURA L; RAINES RONALD T; ALLEN MATTHEW J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble.