CAS: 7423-55-4; 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Propanoic Acid

相似化合物

57078-98-5 57078-99-6 55750-53-3

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CAS号108-31-6 顺酐 | CAS号107-95-9 β-丙氨酸 | CAS号57079-11-5 顺-5-氮杂-4-氧代-辛-2-烯二酸 | CAS号64-19-7 冰醋酸 | CAS号55750-62-4 3-马来酰亚胺丙酸 N-羟基琥珀酰亚胺酯 | CAS号57-13-6 尿素 | CAS号22011-03-6 methyl 3-(2,5-d... | CAS号121215-45-0 propanoyl chlor...

顺式-5-氮杂-4-氧代-辛-2-烯-二酸置于溶剂黄146体系中,化学反应 8.0H,以2.74 G的收率获得产物3-马来酰亚胺基丙酸
参考文献:自我复制与反应性二元复合物--通过简单的结构修饰来操纵识别介导的环加成.
标题:自我复制与反应性二元复合物--通过简单的结构修饰来操纵识别介导的环加成.
摘要:通过在反应物种类上引入互补识别位点,可以提高呋喃和马来酰亚胺之间的 Diels-Alder 环加成反应速率和选择性.其他结构元素的微妙操作允许通过自我复制或形成预反应二元复合物来产生观测到的速率增强和选择性.
DOI:10.1039/b406862A

专利信息

专利号:US-2010035799-A1
优先权日:2002-07-24
标 题:Method for the synthesis of anthracycline-peptide conjugates
发明人：FERNANDEZ ANNE-MARIE; DUBOIS VINCENT
权利人:UNIV CATHOLIQUE LOUVAIN; DIATOS SA
摘要:The present invention relates to a method for the preparation of a compound of formula (I) or pharmaceutically acceptable salts thereof and intermediates thereof, comprising the steps of: n n n n n n n n n n n n a) halogenating a compound of formula (II), resulting in compound of formula (IIa), n n n n n n n n n n n n n n n n b) reacting a compound of formula (IIa) at its 14 position with the thiol moiety of a peptide of formula (III), optionally in the presence of a suitable linker, to obtain said compound of formula (I), n n n n n n n n n n n n n n n n wherein R 1 represents OH, NH 2 or NH-peptide; R 2 represents H or —CO-peptide; R 3 represents OCH 3 , OH or H; R 4 represents H, or COCF 3 ; R 5 represents OH, O-tetrahydropyranyl or H; R 6 represents OH or H; R 7 represents H, OH, OCO(CH 2 ) 3 CH 3 or OCOCH(OC 2 H 5 ) 2 ; R 8 represents OH or H; R 9 represents OH or H; R 10 represents a halogen and L is an optional suitable linker arm.

专利号:US-2006183886-A1
优先权日:1995-11-22
标题:Ligands to enhance cellular uptake of biomolecules
发明人：TSO PAUL O; DUFF ROBERT; ZHOU YUANZHONG; DEAMOND SCOTT; ROBY CLINTON
权利人:CELL WORKS THERAPEUTICS INC A
摘要:The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payloadâ€? to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway.

专利号:US-2008267981-A1
优先权日:2004-06-30
标题:Compositions and Methods for Delivery of Antitumor Agents
发明人：JANDA KIM D; WIRSCHING PETER; BOGER DALE L
权利人:SCRIPPS RESEARCH INST
摘要:Methods for treating a neoplastic disease with an antibody-cytotoxin conjugate molecule, methods of synthesizing an antibody-cytotoxin conjugate molecule are provided. Compounds that are useful as antibody-cytotoxin conjugate molecule or useful in the synthesis of these molecules are also provided.

专利号:US-2008207523-A1
优先权日:2006-09-08
标题 :Compounds as aptamer-dimers and their uses in diagnosis and therapy
发明人：FRIEBE MATTHIAS; STEPHENS ANDREW; SRINIVASAN ANANTH; HECHT MAREN
权利人:FRIEBE MATTHIAS; STEPHENS ANDREW; SRINIVASAN ANANTH; HECHT MAREN
摘要:The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent. n In another preferred embodiment the present invention relates to a kit for preparing a radiopharmaceutical preparation, said kit comprising a vial comprising a quantity of the compound according to the invention. n A further preferred embodiment of the present invention relates to methods of producing said compounds, comprising synthesis of said compound in an automated peptide synthesizer. n In another preferred embodiment the present invention concerns the use of said compounds according to the present invention for the manufacture of a medicament, preferably for diagnosis or therapy of proliferative diseases. n In a further preferred embodiment the present invention concerns methods for treating or diagnosing patients administering or utilizing the compounds according to the present invention.

专利号:US-6221602-B1
优先权日:1998-11-10
标题:Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
发明人：BARBERA-GUILLEM EMILIO; NELSON M BUD; CASTRO STEPHANIE L
权利人:BIO PIXELS LTD
摘要:Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities. Also provided are kits comprising a plurality of species of functionalized nanocrystal-labeled nucleobases. The functionalized nanocrystal-labeled nucleobases may be added to a strand synthesis reaction under suitable conditions to be incorporated into one or more strands synthesized in the reaction.

专利号:WO-0028089-A1
优先权日:1998-11-10
标 题:Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
发明人：BARBERA-GUILLEM EMILIO; NELSON M BUD; CASTRO STEPHANIE
权利人:BIOCRYSTAL LTD
摘要:Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities. Also provided are kits comprising a plurality of species of functionalized nanocrystal-labeled nucleobases. The functionalized nanocrystal-labeled nucleobases may be added to a strand synthesis reaction under suitable conditions to be incorporated into one or more strands synthesized in the reaction.