CAS: 67174-25-8; (1S,2S,4S,5R)-1-Benzyl-2-((R)-Hydroxy(6-Methoxyquinolin-4-yl)Methyl)-5-Vinylquinuclidin-1-Ium Chloride

相似化合物

69221-14-3 69257-04-1 95088-20-3

上下游产品

CAS号100-44-7 氯化苄 | CAS号130-95-0 奎宁； 无水奎宁； 金鸡纳碱； 金鸡纳霜

📜氯化苄,奎宁 以 四氢呋喃 作为反应溶剂,化学反应 12.0H,反应生成 N-苄基奎宁氯
参考文献:使用λ萘酚的非对称dearomative Spirolactonization 3个手性相转移催化-Iodanes
标题:使用λ萘酚的非对称dearomative Spirolactonization 3个手性相转移催化-Iodanes
摘要:手性的不对称相转移催化效果金鸡纳生物碱类季铵盐在λ的情况下进行了研究3萘酚的-Iodane介导dearomative Spirolactonization.使用各种底物评估了该方法的范围和局限性,这些底物以非常好的产率转化为螺内酯,对映体过量最高可达58%.
DOI:10.1016/j.Tet.2017.04.028

专利信息

专利号:US-5510528-A
优先权日:1993-04-08
标题:Preparation of halomethylbenzoly cyanides and novel halomethylbenzoyl cyanides
发明人：ISAK HEINZ; WETTLING THOMAS; KEIL MICHAEL; WOLF BERND; DOETZER REINHARD
权利人:BASF AG
摘要:A process for preparing halomethylbenzoyl cyanides I n n Ph-CO-CN I n n (Ph=phenyl radical substituted by chloromethyl or bromomethyl which, if desired, can additionally carry 1-4 further radicals) by reacting halomethylbenzoyl chlorides II n n Ph-CO-Cl II n n with an alkali metal cyanide or transition metal cyanide, if appropriate in an organic diluent, and novel halomethylbenzoyl cyanides I' ##STR1## (X=halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, CF 3 , C 1 -C 5 -alkyl-(C 1 -C 5 -alkyl)hydroxyimino or C 1 -C 5 -alkyl-(C 2 -C 5 -alkenyl)hydroxyimino; m=0 to 4 and Y=chloromethyl or bromomethyl) are described. n The halomethylbenzoyl cyanides I are important intermediates for the synthesis of plant protection agents.

专利号:US-7098342-B2
优先权日:2003-10-16
标题 :Preparation of candesartan cilexetil
发明人：ETINGER MARINA YU; FEDOTEV BORIS; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.

专利号:US-2008241949-A1
优先权日:2007-03-29
标 题 :Process for preparing quetiapine fumarate
发明人：KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
权利人:KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
摘要:Provided is an improved synthesis of quetiapine and pharmaceutically acceptable salts.

专利号:US-7687622-B2
优先权日:2005-04-14
标 题 :Process for preparing quetiapine fumarate
发明人：KANSAL VINOD KUMAR; LAL KANHAIYA; AHMAD SUHAIL; LEONOV DAVID
权利人:TEVA PHARMA
摘要:Provided is a novel synthesis of quetiapine, and pharmaceutically acceptable salts thereof, in which an alkali metal halide or siliyl halide is included in the reaction mixture.