CAS: 639-14-5; Gypsogenin

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CAS号465-99-6 常春藤皂苷元 | CAS号582-16-1 2,7-二甲基萘 | CAS号108368-99-6 6-Hydroxy-1.2.5... | CAS号486-34-0 Naphthalene, 1,... | CAS号1679-02-3 2,9-Dimethylpicene | CAS号641-91-8 1,2,5-三甲基萘

📜常春藤皂苷元置于n-氯代丁二酰亚胺,2,2,6,6-四甲基哌啶氧化物,四丁基氯化铵,碳酸氢钠,Potassium Carbonate体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以72%的收率获得产物(3β,4α)-3-羟基-23-氧代齐墩果-12-烯-28-酸
参考文献: Minimal Saponin Analogues,Synthesis And Use Thereof[fr] Analogues De Saponine à Structure Minimale,Synthèse Et Utilisation
标题: Minimal Saponin Analogues,Synthesis And Use Thereof[fr] Analogues De Saponine à Structure Minimale,Synthèse Et Utilisation
摘要:披露了含有三糖或四糖酯的截短三萜皂苷类似物.还披露了包含截短皂苷类似物的药物组合物以及生产截短皂苷类似物的合成方法.本申请的另一个方面涉及一种免疫主体的方法,包括向主体施用包含最小皂苷类似物和抗原的药物组合物.

专利信息

专利号:US-9943544-B2
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
发明人：BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.

专利号:WO-2025198574-A1
优先权日:2024-03-22
标题 :Gypsogenin-amine semisynthesis derivative compounds with anticancer activity and synthesis methods of these compounds
发明人：EMÄ°RDAÄž SAFIYE; ULUSOY AKKUM NAFIA GÖKÇE; AKSEL MEHRAN
权利人:EGE UENIVERSITESI IDARI VE MALI ISLERDAIRE BSK; AYDIN ADNAN MENDERES UENIVERSITESI REKTOERLUEGUE IDARI VE MALI ISLER DAIRE BASKANLIGI
摘要:The invention relates to the gypsogenin-amine semisynthesis derivative compounds with anticancer activity and synthesis methods of these compounds. The gypsogenin-amine semisynthesis derivative compounds of the invention are derivatized from gypsogenin-amine aglycone.

专利号:US-8257754-B2
优先权日:2002-10-21
标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

专利号:US-8486457-B2
优先权日:2002-10-21
标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

专利号:US-8557306-B2
优先权日:2001-06-20
标 题 :Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

专利号:US-2016271177-A1
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer