CAS: 5391-39-9; 1-Acetylimidazolidin-2-One

相似化合物

6843-45-4 5391-39-9 2221-20-7

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2-咪唑烷酮,1-乙酰基-1H-苯并噻唑置于potassium Carbonate体系中,用 甲苯 作为反应溶剂,化学反应 2.5H,以87%的收率获得产物n-乙酰基-2-咪唑烷酮
参考文献:A Novel And Efficient Reaction Of Imidazolidin-2-One Andn-Acylbenzotriazoles: A Facile Synthesis Of 1-Acylimidazolidin-2-One
标题:A Novel And Efficient Reaction Of Imidazolidin-2-One Andn-Acylbenzotriazoles: A Facile Synthesis Of 1-Acylimidazolidin-2-One
摘要:Acylation Of Imidazolidin-2-One With Readily Available N-Acylbenzotriazoles,In The Presence Of K2Co3,Produced 1-Acylimidazolidin-2-Ones And N,N'-Diacyl-Imidazolidin-2-One In Moderate To Good Yields. The Utilization Of N-Acylbenzotriazoles Which Make The Reaction Simple And Mild,May Be Especially Advantageous When The Corresponding Acid Chlorides Are Not Stable Or Not Easily Prepared. It'S Also An Example Of The Reaction Of N-Acylbenzotriazoles And Amide.
DOI:10.1080/00397910903531615

专利信息

专利号:WO-2015011010-A1
优先权日:2013-07-26
标 题:Synthesis of substituted aminopyrimidines
发明人：ACQUASALIENTE MAURIZIO; LAGERWEIJ GERT; DESHPANDE MAHENDRA; SHAH RAJENDRA
权利人:ABBOTT HEALTHCARE PRODUCTS BV; ABBOTT LAB
摘要:The present invention relates to a novel process for the manufacture of certain substituted aminopyrimidines having Formula (I) or a tautomer or salt thereof, wherein R 1 is selected from hydrogen, halogen, C 1-4 alkoxy, C 1-4 alklthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example R1 is halogen such as chloro; R2 is C 1-4 alkyl, for example methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), such as methyl; and R3 is selected from hydrogen, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example C 1-4 alkyl such as methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), for example methyl; crystalline forms thereof as well as chemical intermediates suitable for use in performing the process.

专利号:EP-2829540-A1
优先权日:2013-07-26
标 题 :Synthesis of substituted aminopyridines

专利号:CN-1446802-A
优先权日:2002-03-22
标 题 :Chemical synthesis method of 1-chloroformyl-3-acetyl-2-imidazolidinone