CAS: 4985-46-0; H-Tyr-Nh2

该化合物是氨基酸L-Tyrosine的衍生物,其特点是在碳酸酯终点点进行氨化物组替代,这种改变增强了其稳定性和溶性,使其成为浸泡物合成和制药应用中有价值的中间体.该化合物保留了L-Tyrosine的生物活性特性,包括其作为多巴胺和无肾上腺素等...

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tyrosinamide L-tyrosine methyl ester HCl L-Tyr-OMe tyrosine ethyl esterN-trichloroacetyl-L-tyrosine amideN-trichloroacetyl-L-tyrosine amide N-(S-benzyl-N-benzyloxycarbonyl-L-cysteinyl)-L-tyrosine amideN-(S-benzyl-N-benzyloxycarbonyl-L-cysteinyl)-L-tyrosine amide N-ethoxycarbonyl-L-tyrosine amideN-ethoxycarbonyl-L-tyrosine amide N-chloroacetyl-L-tyrosine amideN-chloroacetyl-L-tyrosine amide

合成工艺路线路线简述

    📜L-酪氨酸 以 甲醇 作为反应溶剂,化学反应生成 L-酪氨酰胺
    参考文献:Chelating Agents And Method
    标题:Chelating Agents And Method
    摘要:公开了一种从α氨基酸的酰胺衍生物制备edta,Ed3A或dtpa类似物的简单方法.这些edta,Ed3A或dtpa类似物是有用的螯合剂,最好用作双功能螯合剂,可以附着在生物分子上,并与各种金属离子形成生理稳定的螯合物.

    海关参考信息

    专利信息


    专利号:US-2018312463-A1
    优先权日:2015-10-22
    标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
    发明人:YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
    权利人:PROCTER & GAMBLE
    摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

    专利号:US-6309842-B1
    优先权日:1996-12-03
    标 题:Use of modified tethers in screening compound libraries
    发明人:DOWER WILLIAM J; GATES CHRISTIAN M; HEINKEL GREGORY L; LALONDE GUY; MATTHEAKIS LARRY C; PADDON CHRISTOPHER J; SCHATZ PETER J
    权利人:GLAXO WELLCOME INC
    摘要:The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.

    专利号:US-12162853-B2
    优先权日:2018-10-22
    标题:Synthesis of esuberaprost prodrugs
    发明人:BATRA HITESH; GUO LIANG
    权利人:UNITED THERAPEUTICS CORP
    摘要:Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.

    专利号:US-2024052097-A1
    优先权日:2021-02-08
    标题 :Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties
    发明人:LIN CHIEN-CHI; LIN FANG-YI
    权利人:UNIV INDIANA TRUSTEES
    摘要:Methods for synthesizing a hydrogel having tunable hydrolylic degradation kinetics according to certain embodiments include synthesizing a norborene-functionalized polyethylene glycol macromer having an ester linkage between a polyethylene glycol domain of the macromer and a norbornene domain of the macromer and having a carboxyl group on the norbornene; and reacting a quantity of such macromers with a quantity of dithiol molecules by an ultraviolet-initiated photo-gelation reaction to yield a hydrogel. Such macromers and such hydrogels form additional aspects of the disclosure, as do a wide variety of methods for tuning and for using such hydrogels.

    专利号:US-7060678-B2
    优先权日:2003-08-08
    标 题:Peptides comprising furanoid sugar amino acids for the treatment of cancer
    发明人:PRASAD SUDHANAND; CHAKRABORTY TUSHAR KANTI; MATHUR ARCHNA; JAGGI MANU; KUNWAR AJIT CHAND; MUKHERJEE RAMA; BURMAN ANAND C
    权利人:DABUR RES FOUNDATION
    摘要:Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.

    专利号:US-6906158-B2
    优先权日:2003-03-13
    标 题 :Compositions and methods of vinyl oxazolone polymerization
    发明人:TULLY DAVID
    权利人:IRM LLC
    摘要:This invention provides novel methods for synthesis of narrow polydispersity oxazolone-containing polymers via nitroxide-mediated living free radical polymerization, as well as the products and derivatives thereof.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Vianini E, Palumbo M, Gatto B. In vitro selection of DNA aptamers that bind L-tyrosinamide. Bioorg Med Chem. 2001 Oct;9(10):2543-8. doi: 10.1016/s0968-0896(01)00054-2.
    102:653-660. doi: 10.1016/j.msec.2019.04.093. Epub 2019 Apr 30. 112(21):6665-73. doi: 10.1021/jp8000866. Epub 2008 May 6.

    合成参考文献


    参考文献:10.1021/ja0164327
    摘要:Ayala I, Range K, York D, Barry BA. Spectroscopic properties of tyrosyl radicals in dipeptides. J Am Chem Soc. 2002 May 15;124(19):5496–505. doi: 10.1021/ja0164327.
    参考文献:10.1016/s0021-9258(18)70249-4
    摘要:Zioudrou C, Fruton JS. Labeling of Mitochondrial Proteins by C14-Tyrosinamide and C14-Tyrosyladenylate. Journal of Biological Chemistry. 1959 Mar;234(3):583–5. doi: 10.1016/s0021-9258(18)70249-4.
    摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
    摘要:R. B. Martin, J. T. Edsall, D. B. Wetlaufer, and B. R. Hollingworth. J. Biol. Chem. 233, 1429 (1958).
    摘要:R. W. Chambers and F. H. Carpenter. J. Am. Chem. Soc. 77, 1522 (1955).
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