CAS: 4743-17-3; 6-Chloro-1H-Benzo[d][1,3]Oxazine-2,4-Dione

上下游产品

CAS号32315-10-9 三光气 | CAS号635-21-2 2-氨基-5-氯苯甲酸 | CAS号2148-56-3 2-氨基-6-氯苯甲酸 | CAS号75-36-5 乙酰氯 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号17422-32-1 5-氯吲哚 | CAS号118-48-9 靛红酸酐 | CAS号17630-76-1 5-氯靛红 | CAS号51108-30-6 4-氯异二氢吲哚-1,3-二酮 | CAS号117-21-5 3-氯苯酐 | CAS号5202-85-7 2-氨基-5-氯苯甲酰胺 | CAS号5177-39-9 7-氯-3,4-二氢-1H-苯... | CAS号41632-04-6 2-氨基-6-氯苯甲酸甲酯 | CAS号19178-37-1 2-氨基-5-氯-N-甲基苯甲酰胺 | CAS号229343-30-0 2-amino-5-chlor... | CAS号719-59-5 2-氨基-5-氯二苯甲酮 | CAS号77820-58-7 2-氨基-3-氯苯甲酸甲酯 | CAS号635-21-2 2-氨基-5-氯苯甲酸 | CAS号57756-37-3 7-氯-2,3,4,5-四氢-... | CAS号5584-15-6 2-氨基-5-氯苯甲酰肼

📜5-氯靛红置于间氯过氧苯甲酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 5-氯靛红酸酐
参考文献:色胺菊酯及其衍生物的发现及其通过细胞凋亡和自噬途径体外抗 Nsclc 的活性.
标题:色胺菊酯及其衍生物的发现及其通过细胞凋亡和自噬途径体外抗 Nsclc 的活性.
摘要:在这项研究中,合成了一系列新型色胺酮衍生物,并评估了它们对选定的人类癌细胞系,即肺癌 (A549),慢性粒细胞白血病 (K562),前列腺 (Pc3) 和活细胞 (Hepg2) 的抑制活性使用甲基噻唑基四唑鎓比色法 (Mtt) 测定.在测试的化合物中,化合物 C1 对 A549 细胞系表现出非常好的抑制作用,Ic50 值为 0.55 +/-0.33 µm.通过细胞迁移实验观察细胞形态学结果表明,C1处理可显着抑制a549细胞的迁移.此外,经c1处理后,A549细胞表现出典型的凋亡形态和明显的自噬.此外,细胞凋亡和线粒体膜电位的检测表明,C1通过调节bcl2家族成员的水平并破坏线粒体膜电位来诱导a549细胞凋亡.化合物c1还抑制细胞周期蛋白d1的表达并增加a549细胞中p21的表达,以剂量依赖的方式诱导细胞周期停滞在g2/m期.进一步的机制研究发现,C1 显着增加了从 Lc3-I 到 Lc3-Ii
DOI:10.3390/ijms24021450

专利信息

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-4713383-A
优先权日:1984-10-01
标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
发明人：FRANCIS JOHN E; GELOTTE KARL O
权利人:CIBA GEIGY CORP
摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

专利号:US-6187923-B1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS ADVANCED TECHNOLOGIES INC
摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:

专利号:WO-0027831-A1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones

专利号:RU-2024523-C1
优先权日:1989-09-08
标 题:Method of synthesis of tetrahydro-[1,4]-benzodiazepine-2-thiones or their pharmaceutically acceptable acid additive salts or stereochemical isomers

专利号:WO-2009138985-A2
优先权日:2008-05-15
标 题:Coupling agents for the synthesis of polypeptides and polynucleotides