CAS: 446292-08-6; (S)-2-((2-Oxo-3-(4-(3-Oxomorpholino)Phenyl)Oxazolidin-5-yl)Methyl)Isoindoline-1,3-Dione

相似化合物

446292-08-6 1365267-36-2 1265617-06-8

上下游产品

2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione 1,1'-carbonyldiimidazole (S)-N-glycidylphthalimide 4-(4-aminophenyl)morpholin-3-one 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydr°Chloride (S)-2-(((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)carbamoyl)benzoic acid 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate Rivaroxaban

(R)-2-Hydroxy-3-(4-(3-Oxo-Morpholino)Phenylamino)Propyl Butyrate置于盐酸,4-二甲氨基吡啶,水,Potassium Carbonate,三乙胺,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 35.0H,反应生成 2-[[(5S)-2-氧代-3-[4-(3-氧代-4-吗啉基)苯基]-5-噁唑烷基]甲基]-1H-异吲哚-1,3(2H)-二酮
参考文献:Processes And Intermediates For Preparing Rivaroxaban
标题:Processes And Intermediates For Preparing Rivaroxaban
摘要:该发明揭示了制备利伐罗班及其药用可接受盐,溶剂合物和水合物的过程.该发明还涉及用于制备利伐罗班的新型中间体.

专利信息

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:WO-2013027225-A1
优先权日:2011-08-19
标 题:Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.

专利号:WO-2015198259-A1
优先权日:2014-06-26
标 题:Process for the synthesis of rivaroxaban and intermediate for the production thereof
发明人：FERRARI MASSIMO; GHEZZI EMANUELE; GHEZZI MARCELLO
权利人:ERREGIERRE SPA
摘要:A process is described for the production of Rivaroxaban, a compound having the following structural formula: (I) by means of obtaining a novel intermediate of said process.

专利号:RU-2383540-C2
优先权日:2004-01-15
标 题 :Method for synthesis of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide